Synchronous Polymorphous Adenocarcinoma and Canalicular Adenoma on the Upper Lip: An Unusual Presentation and Immunohistochemical Analysis

Autor(es)

Ortega, Rose Mara ^{[1, 2]} ; Bufalino, Andreia ^[1] ; Almeida, Luciana Yamamoto ^[1] ; Navarro, Claudia Maria ^[1] ; Travassos, Daphine Caxias ^[1] ; Ferrisse, Tulio Morandin ^[1] ; Carlos, Roman ^[3] ; Leon, Jorge Esquiche ^[4]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Araraquara Dent Sch, Dept Diag & Surg, Oral Med, Sao Paulo - Brazil

^[2] Fed Univ Juiz de Fora UFJF GV, Oral Med, Rua Israel Pinheiro 2-000, BR-35020220 Governador Valadares, MG - Brazil

^[3] Ctr Clin Cabeza & Cuello, Guatemala City - Guatemala

^[4] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Head and Neck Pathology; v. 12, n. 1, p. 145-149, MAR 2018.
• Citações Web of Science: 2

Resumo

Multiple salivary gland tumors (MSGTs) are most common in the major than minor salivary glands. The most MSGTs are synchronous, either benign or malignant. A 61-year-old woman was referred presenting nine submucosal nodules, firm to fluctuant, being five nodules on the right side and four nodules on the left side of the upper lip. An incisional biopsy was performed. Hematoxylin and eosin staining was performed in 5-mu m sections for histopathologic analysis. Immunohistochemical reactions were carried out in 3-mu m sections in accordance with manufacturer's instructions. The histopathological analysis showed focal area containing low-grade polymorphous adenocarcinoma (PAC) and multiple canalicular adenomas (CAs). Immunohistochemical analysis for each lesion was carefully investigated. Here, we present an unusual case of synchronous PAC and multiple CAs of the minor salivary glands, affecting the upper lip, which appears to be the first case showing PAC and CA. (AU)

• Processo FAPESP: 14/50256-4 - Aquisição de sistema de densitometria óssea, sistema de microarranjo tecidual, leitor de placa e termociclador em tempo real para estudo da matriz extracelular
• Beneficiário: Heloisa Sobreiro Selistre de Araújo
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 16/11419-0 - Correlação clinicopatológica do grau de diferenciação, expressão de tetraspaninas, agentes virais e proliferação celular em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço.
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/52090-8 - Análise imunoistoquímica comparativa de células dendríticas, linfócitos citotóxicos e expressão de indolamina 2,3-dioxigenase em desordens potencialmente malignas e carcinomas espinocelulares oral e do lábio inferior
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular