Synchronous Polymorphous Adenocarcinoma and Canalicular Adenoma on the Upper Lip: An Unusual Presentation and Immunohistochemical Analysis

Author(s)

Ortega, Rose Mara ^{[1, 2]} ; Bufalino, Andreia ^[1] ; Almeida, Luciana Yamamoto ^[1] ; Navarro, Claudia Maria ^[1] ; Travassos, Daphine Caxias ^[1] ; Ferrisse, Tulio Morandin ^[1] ; Carlos, Roman ^[3] ; Leon, Jorge Esquiche ^[4]

Affiliation

^[1] Univ Estadual Paulista UNESP, Araraquara Dent Sch, Dept Diag & Surg, Oral Med, Sao Paulo - Brazil

^[2] Fed Univ Juiz de Fora UFJF GV, Oral Med, Rua Israel Pinheiro 2-000, BR-35020220 Governador Valadares, MG - Brazil

^[3] Ctr Clin Cabeza & Cuello, Guatemala City - Guatemala

^[4] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Head and Neck Pathology; v. 12, n. 1, p. 145-149, MAR 2018.
• Web of Science Citations: 2

Abstract

Multiple salivary gland tumors (MSGTs) are most common in the major than minor salivary glands. The most MSGTs are synchronous, either benign or malignant. A 61-year-old woman was referred presenting nine submucosal nodules, firm to fluctuant, being five nodules on the right side and four nodules on the left side of the upper lip. An incisional biopsy was performed. Hematoxylin and eosin staining was performed in 5-mu m sections for histopathologic analysis. Immunohistochemical reactions were carried out in 3-mu m sections in accordance with manufacturer's instructions. The histopathological analysis showed focal area containing low-grade polymorphous adenocarcinoma (PAC) and multiple canalicular adenomas (CAs). Immunohistochemical analysis for each lesion was carefully investigated. Here, we present an unusual case of synchronous PAC and multiple CAs of the minor salivary glands, affecting the upper lip, which appears to be the first case showing PAC and CA. (AU)

• FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
• Grantee: Jorge Esquiche León
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/52090-8 - Comparative immunohistochemical analysis of dendritic cells, cytotoxic lymphocytes, and indolamine 2,3-dioxigenase expression in potentially malignant disorders and squamous cells carcinoma of the oral cavity and lower lip
• Grantee: Jorge Esquiche León
• Support Opportunities: Regular Research Grants