Polymorphous Low-Grade Adenocarcinoma: Growth Factors , apoptosis , autophagy and senescence , vascularization , oxidative stress and gene analysis .

• Grant number: 15/12418-5
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2015
• End date: October 31, 2017
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Vera Cavalcanti de Araujo
• Grantee: Vera Cavalcanti de Araujo
• Host Institution: Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Campinas , SP, Brazil
• Associated researchers: Cristiane Furuse ; Maria Cassia Ferreira de Aguiar ; Victor Angelo Martins Montalli

Abstract

Polymorphous low-grade adenocarcinoma (PLGA) is a malignant epitelial tumor characterized by cytological uniformity, morphological diversity, infiltrative growth pattern and low metastatic potential. Despite our improved understanding of this entity over time, differences found among the studies worldwide indicate that diagnosing PLGA remains challenging, probably because histological and cytological criteria are not uniformly applied. Due to the importance of this pathology, mainly in its intraoral localization, as well as its high invasion potential, we have endeavour to ameliorate the knowledge on this tumor biology, which may lead to significant improvement in patient survival and quality of life. This multicenter study aims to analyse the immunnohistochemical aspects related to growth factors and their receptors, vascularization, apoptosis, autophagy and senescence, recent markers of salivary gland tumors, cell proliferation and oxidative stress as well as cytogenetic analysis of potential ETV6-NTRK3 fusion and molecular analysis of the PRKD1 mutation. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GARCIA ROSA, ANA CLAUDIA; SOARES, ANDRESA BORGES; SANTOS, FABRICIO PASSADOR; FURUSE, CRISTIANE; DE ARAUJO, VERA CAVALCANTI. Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 45, n. 7, p. 494-499, AUG 2016. (15/12418-5)

MARTINS MONTALLI, VICTOR ANGELO; PASSADOR-SANTOS, FABRICIO; MARTINEZ, ELIZABETH FERREIRA; FURUSE, CRISTIANE; AGUIAR, MARIA CASSIA; SOARES, FERNANDO AUGUSTO; SOARES, ANDRESA BORGES; BROWN, AMY LOUISE; DE ARAUJO, NEY SOARES; DE ARAUJO, VERA CAVALCANTI. Mammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 46, n. 3, p. 182-187, MAR 2017. (15/12418-5)

BROD, J. M.; DIAS DEMASI, ANA PAULA; MONTALLI, V. A.; TEIXEIRA, L. N.; FURUSE, C.; AGUIAR, M. C.; SOARES, A. B.; SPERANDIO, M.; ARAUJO, V. C.. Nrf2-peroxiredoxin I axis in polymorphous adenocarcinoma is associated with low matrix metalloproteinase 2 level. Virchows Archiv, v. 471, n. 6, p. 793-798, DEC 2017. (15/12418-5)

SOARES, ANDRESA BORGES; MARTINEZ, ELIZABETH FERREIRA; AVILA RIBEIRO, PATRICIA FERNANDES; BARRETO, ICLEIA SIQUEIRA; AGUIAR, MARIA CASSIA; FURUSE, CRISTIANE; SPERANDIO, MARCELO; MONTALLI, VICTOR ANGELO; DE ARAUJO, NEY SOARES; DE ARAUJO, VERA CAVALCANTI. Factors that may influence polymorphous low-grade adenocarcinoma growth. Virchows Archiv, v. 470, n. 4, p. 437-443, APR 2017. (15/12418-5)