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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Gastric fundus submucosa as a site for islets transplantation: An experimental study

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Autor(es):
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Antunes de Mesquita, Gustavo Heluani [1] ; Jardim, Yuri Justi [1] ; Iuamoto, Leandro Ryuchi [1] ; Suguita, Fabio Yuji [1] ; Essu, Felipe Futema [1] ; Oliveira, Lucas Torres [1] ; Meyer, Alberto [2, 3] ; Crescenzi, Alessandra [2] ; Rocha-Santos, Vinicius [2] ; Galvao, Flavio H. F. [2] ; Andraus, Wellington [3] ; Chaib, Eleazar [2] ; Carneiro D'Albuquerque, Luiz Augusto [2, 3]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med FMUSP, Dr Nicolau de Souza Queiros St, 406, Apartment 92, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Div Transplante Figado, LIM 37, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Gastroenterol, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: ANNALS OF MEDICINE AND SURGERY; v. 28, p. 1-5, APR 2018.
Citações Web of Science: 0
Resumo

Background: Islets of Langerhans transplantation is a promising alternative for glycemic control in patients with type 1 diabetes. The graft site is a factor that has large impact on the functioning of this transplant, and the stomach appears to be a promising location. Our objective is to describe a new experimental model for the grafting of Islets of Langerhans in rat stomachs. Methodology: Islets of Langerhans were extracted from 45 isogenic male rats of the Lewis lineage and transplanted into 9 isogenic rats of the Wistar lineage; 5 in the gastric body submucosa, and 4 in the gastric fundus submucosa. Normoglycemia was defined as two successive measurements of < 250 mg/dL. No immunosuppression was used. The two groups glycemia control improvement were compared with t-student test. Results: The results obtained following the transplantation of the islets in 9 rats showed between 995 and 2310 islets transplanted (mean of 1367). The rats from the gastric submucosa group had a better glycemic level improvement, with a confidence equal to 83.94%. Conclusion: Islets graft into the gastric fundus submucosa is a viable model with potential for adequate glycemic control. This model gives potential for new perspectives and future studies in this area. (AU)

Processo FAPESP: 14/18202-1 - Efeitos do uso da imunossupressão com rapamicina ou ciclosporina associada ao micofenolato mofetil no alotransplante de Ilhotas de Langerhans em estômagos de ratos
Beneficiário:Alberto Luiz Monteiro Meyer
Linha de fomento: Bolsas no Brasil - Pós-Doutorado