| Texto completo | |
| Autor(es): Mostrar menos - |
Antunes de Mesquita, Gustavo Heluani
[1]
;
Jardim, Yuri Justi
[1]
;
Iuamoto, Leandro Ryuchi
[1]
;
Suguita, Fabio Yuji
[1]
;
Essu, Felipe Futema
[1]
;
Oliveira, Lucas Torres
[1]
;
Meyer, Alberto
[2, 3]
;
Crescenzi, Alessandra
[2]
;
Rocha-Santos, Vinicius
[2]
;
Galvao, Flavio H. F.
[2]
;
Andraus, Wellington
[3]
;
Chaib, Eleazar
[2]
;
Carneiro D'Albuquerque, Luiz Augusto
[2, 3]
Número total de Autores: 13
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Fac Med FMUSP, Dr Nicolau de Souza Queiros St, 406, Apartment 92, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Div Transplante Figado, LIM 37, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Gastroenterol, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ANNALS OF MEDICINE AND SURGERY; v. 28, p. 1-5, APR 2018. |
| Citações Web of Science: | 0 |
| Resumo | |
Background: Islets of Langerhans transplantation is a promising alternative for glycemic control in patients with type 1 diabetes. The graft site is a factor that has large impact on the functioning of this transplant, and the stomach appears to be a promising location. Our objective is to describe a new experimental model for the grafting of Islets of Langerhans in rat stomachs. Methodology: Islets of Langerhans were extracted from 45 isogenic male rats of the Lewis lineage and transplanted into 9 isogenic rats of the Wistar lineage; 5 in the gastric body submucosa, and 4 in the gastric fundus submucosa. Normoglycemia was defined as two successive measurements of < 250 mg/dL. No immunosuppression was used. The two groups glycemia control improvement were compared with t-student test. Results: The results obtained following the transplantation of the islets in 9 rats showed between 995 and 2310 islets transplanted (mean of 1367). The rats from the gastric submucosa group had a better glycemic level improvement, with a confidence equal to 83.94%. Conclusion: Islets graft into the gastric fundus submucosa is a viable model with potential for adequate glycemic control. This model gives potential for new perspectives and future studies in this area. (AU) | |
| Processo FAPESP: | 14/18202-1 - Efeitos do uso da imunossupressão com rapamicina ou ciclosporina associada ao micofenolato mofetil no alotransplante de Ilhotas de Langerhans em estômagos de ratos |
| Beneficiário: | Alberto Luiz Monteiro Meyer |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |