Is it possible to use Forensic DNA phenotyping in Brazilian population?

Autor(es)

Fridman, Cintia ^[1] ; Siria Godoy Cardena, Mari Maki ^[1] ; Lima, Felicia de Araujo ^[1] ; Goncalves, Fernanda de Toledo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept Legal Med Eth & Occupat Hlth, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES; v. 5, p. E378-E380, DEC 2015.
• Citações Web of Science: 2

Resumo

The prediction of human traits in order to help forensic investigations has been one of the most interesting researches in the last decade. Some pigmentation genes such as SLC45A2 variants have been associated with phenotypic diversity of skin, eyes and hair color in homogeneous populations. The aim of this study was evaluate the possibility of association between three SLC45A2 polymorphisms (rs26722, rs16891982 and 2,278,007) with skin, eye and hair color in a sample of 598 individuals of admixed population from Brazil, intending to use it in forensic genetic situations. DNA sequencing was performed with BigDye Terminator v3.1 and capillary electrophoresis was performed in ABI3130. Presence of rs16891982 variant (C>G) was associated with non-black skin (OR 16.35; CI 6.014-44.5), as well as with non-black hair (OR 18.12. CI 5.25-62.6) and light eyes (OR 5.04; CI 2.6-9.6). Polymorphism rs2278007 in heterozygous (AG) was associated with a lower probability of individual presenting lighter pigmentation of skin and hair. Our data corroborates the findings of other studies in homogeneous populations, suggesting that the analysis of SLC45A2 polymorphisms can be used as a tool to access some phenotypic traits and use to help forensic identifications as molecular predictor of phenotypes also in admixed populations. These results supplement the previous ones we showed in the same population with the genes SLC24A5 and ASIP, and they are part of major project, which aims to study the correlation of several pigmentation genes and skin, hair and eye color in Brazilian population. (C) 2015 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/02043-6 - Predição de fenótipos complexos, como cor de pele, de olhos e de cabelo, a partir de análises genotípicas para fins forenses
• Beneficiário: Cintia Fridman Rave
• Modalidade de apoio: Auxílio à Pesquisa - Regular