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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Structural Insights into Protein-Protein Interactions Involved in Bacterial Cell Wall Biogenesis

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Autor(es):
Laddomada, Federica [1, 2, 3] ; Miyachiro, Mayara M. [4] ; Dessen, Andrea [1, 2, 3, 4]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] CNRS, IBS, F-38044 Grenoble - France
[2] Univ Grenoble Alpes, IBS, F-38044 Grenoble - France
[3] Commissariat Energie Atom & Energies Alternat CEA, IBS, F-38044 Grenoble - France
[4] Brazilian Natl Lab Biosci LNBio, CNPEM, BR-13083100 Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: ANTIBIOTICS-BASEL; v. 5, n. 2 JUN 2016.
Citações Web of Science: 10
Resumo

The bacterial cell wall is essential for survival, and proteins that participate in its biosynthesis have been the targets of antibiotic development efforts for decades. The biosynthesis of its main component, the peptidoglycan, involves the coordinated action of proteins that are involved in multi-member complexes which are essential for cell division (the divisome) and/or cell wall elongation (the elongasome), in the case of rod-shaped cells. Our knowledge regarding these interactions has greatly benefitted from the visualization of different aspects of the bacterial cell wall and its cytoskeleton by cryoelectron microscopy and tomography, as well as genetic and biochemical screens that have complemented information from high resolution crystal structures of protein complexes involved in divisome or elongasome formation. This review summarizes structural and functional aspects of protein complexes involved in the cytoplasmic and membrane-related steps of peptidoglycan biosynthesis, with a particular focus on protein-protein interactions whereby disruption could lead to the development of novel antibacterial strategies. (AU)

Processo FAPESP: 11/52067-6 - Estruturação de complexos macromoleculares da parede bacteriana: biossíntese e virulência
Beneficiário:Andrea Dessen de Souza e Silva
Linha de fomento: Auxílio à Pesquisa - Programa SPEC
Processo FAPESP: 13/02451-0 - Caracterização estrutural de componentes de um complexo essencial para a formação da parede bacteriana
Beneficiário:Mayara Mayele Miyachiro
Linha de fomento: Bolsas no Brasil - Doutorado Direto