Intramolecular radical cyclization approach to access highly substituted indolines and 2,3-dihydrobenzofurans under visible-light

Autor(es)

Caiuby, Clarice A. D. ^[1] ; Ali, Akbar ^[1] ; Santana, Vinicius T. ^[2] ; Lucas, Francisco W. de S. ^[1] ; Santos, Marilia S. ^[1] ; Correa, Arlene G. ^[1] ; Nascimento, Otaciro R. ^[2] ; Jiang, Hao ^[1] ; Paixao, Marcio W. ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Carlos UFSCar, Ctr Excellence Res Sustainable Chem CERSusChem, Dept Chem, Rodovia Washington Luis, Km 235 SP-310, BR-13565905 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Grp Mol Biophys Sergio Mascarenhas, Sao Carlos Inst Phys IFSC USP, Ave Trabalhador Sao Carlense 400, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RSC ADVANCES; v. 8, n. 23, p. 12879-12886, 2018.
• Citações Web of Science: 6

Resumo

The combination of visible-light and tris(trimethylsilyl)silane promoting intramolecular reductive cyclization protocol for the synthesis of functionalized indolines and 2,3-dihydrobenzofurans has been developed. The transformations occur in the absence of transition metal and additional photocatalyst. In addition, quantum yield (phi) was determined and electron paramagnetic resonance spectroscopy was performed to better understand the reaction pathway. (AU)

• Processo FAPESP: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia
• Processo FAPESP: 15/17141-1 - Desenvolvimento e Estudos Mecanísticos de Novas Metodologias Sintéticas para Síntese de Compostos Bioativos
• Beneficiário: Ricardo Samuel Schwab
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs