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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Antimicrobial activity of nano-sized silver colloids stabilized by nitrogen-containing polymers: the key influence of the polymer capping

Texto completo
Autor(es):
Batista, Carin C. S. [1] ; Albuquerque, Lindomar J. C. [1] ; de Araujo, Iris [1] ; Albuquerque, Brunno L. [2] ; da Silva, Fernanda D. [1] ; Giacomelli, Fernando C. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre - Brazil
[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: RSC ADVANCES; v. 8, n. 20, p. 10873-10882, 2018.
Citações Web of Science: 8
Resumo

Synthesis of stable silver colloids was achieved using nitrogen-containing polymers acting simultaneously as a reducing and stabilizer agent. The polymers polyethyleneimine (PEI), polyvinylpyrrolidone (PVP) and poly(2-vinyl pyridine)-b-poly(ethylene oxide) (PEO-b-P2VP) were used in the procedures. The influence of the surface chemistry and chemical nature of the stabilizer on the cytotoxicity and antimicrobial properties have been evaluated. The produced nanomaterials were found to be non-toxic up to the highest evaluated concentration (1.00 ppm). Nevertheless, at this very low concentration, the AgNPs stabilized by PVP and PEO-b-P2VP were found to be remarkable biocides against bacteria and fungus. On the other hand, we have surprisingly evidenced negligible antimicrobial activity of AgNPs stabilized by positively charged PEI although both (AgNPs and PEI) materials separately are known for their antimicrobial activity as also evidenced in the current investigation. The evidence is claimed to be related to the blocking of Ag+ kinetic release. Accordingly, the antimicrobial effect of nano-sized silver colloids largely depends on the chemical nature of the polymer coating. Possibly, the outstanding colloid stabilization provided by polyethyleneimine slows down Ag+ release thereby hampering its biological activity whereas the poorer stabilization and good ionic transport property of PVP and PEO-b-P2VP allows much faster ion release and cell damage. (AU)

Processo FAPESP: 16/23844-8 - Vesículas poliméricas biodegradáveis e sensíveis ao pH para encapsulação de BIOMACROMOLÉCULAS
Beneficiário:Lindomar Jose Calumby Albuquerque
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 17/00459-4 - Interações biofisicoquímicas na nanobiointerface: a influência das características superficiais e da presença de coroa protéica no processo de internalização celular de nanomateriais
Beneficiário:Fernando Carlos Giacomelli
Linha de fomento: Auxílio à Pesquisa - Regular