Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial activity of nano-sized silver colloids stabilized by nitrogen-containing polymers: the key influence of the polymer capping

Full text
Author(s):
Batista, Carin C. S. [1] ; Albuquerque, Lindomar J. C. [1] ; de Araujo, Iris [1] ; Albuquerque, Brunno L. [2] ; da Silva, Fernanda D. [1] ; Giacomelli, Fernando C. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre - Brazil
[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC - Brazil
Total Affiliations: 2
Document type: Journal article
Source: RSC ADVANCES; v. 8, n. 20, p. 10873-10882, 2018.
Web of Science Citations: 8
Abstract

Synthesis of stable silver colloids was achieved using nitrogen-containing polymers acting simultaneously as a reducing and stabilizer agent. The polymers polyethyleneimine (PEI), polyvinylpyrrolidone (PVP) and poly(2-vinyl pyridine)-b-poly(ethylene oxide) (PEO-b-P2VP) were used in the procedures. The influence of the surface chemistry and chemical nature of the stabilizer on the cytotoxicity and antimicrobial properties have been evaluated. The produced nanomaterials were found to be non-toxic up to the highest evaluated concentration (1.00 ppm). Nevertheless, at this very low concentration, the AgNPs stabilized by PVP and PEO-b-P2VP were found to be remarkable biocides against bacteria and fungus. On the other hand, we have surprisingly evidenced negligible antimicrobial activity of AgNPs stabilized by positively charged PEI although both (AgNPs and PEI) materials separately are known for their antimicrobial activity as also evidenced in the current investigation. The evidence is claimed to be related to the blocking of Ag+ kinetic release. Accordingly, the antimicrobial effect of nano-sized silver colloids largely depends on the chemical nature of the polymer coating. Possibly, the outstanding colloid stabilization provided by polyethyleneimine slows down Ag+ release thereby hampering its biological activity whereas the poorer stabilization and good ionic transport property of PVP and PEO-b-P2VP allows much faster ion release and cell damage. (AU)

FAPESP's process: 17/00459-4 - Biophysicochemical interactions at the nanobiointerface: the effect of surface features and protein corona on the cellular uptake of polymeric assemblies
Grantee:Fernando Carlos Giacomelli
Support Opportunities: Regular Research Grants
FAPESP's process: 16/23844-8 - Biodegradable and pH-responsive polymersomes for gene and protein delivery
Grantee:Lindomar Jose Calumby Albuquerque
Support Opportunities: Scholarships in Brazil - Doctorate