Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems

Autor(es)

Passaroni, Andreia Cristina ^[1] ; Felicio, Marcello Laneza ^[1] ; Kerdahi Leite de Campos, Nelson Leonardo ^[1] ; de Moraes Silva, Marcos Augusto ^[1] ; Yoshida, Winston Bonida ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista HCFMB UNESP, Fac Med Botucatu, Hosp Clin, Dept Surg & Orthoped, Discipline Cardiovasc Surg, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Revista Brasileira de Cirurgia Cardiovascular; v. 33, n. 1, p. 64-71, 2018.
• Citações Web of Science: 1

Resumo

Abstract Objective: To compare the perioperative incidence rates of hemolysis and inflammatory response in patients undergoing coronary artery bypass grafting with the two main types of cardiopulmonary bypass, centrifugal and roller pumps, and establish correlations among hemolytic and inflammatory changes. Methods: This was a prospective, randomized trial of 60 patients assigned to either roller pump (G1, n=30) or centrifugal pump (G2, n=30) bypass. Markers of hemolysis (serum haptoglobin, lactate dehydrogenase [LDH]) and inflammation (interleukin [IL]1ß, IL-6, and TNF-α) were measured and analyzed. Results: There was no significant between-group difference in the variables of interest. In G1, there was a positive association with IL-6 and TNF-α (P<0.01 and P<0.05, respectively). In G2, there was a positive association with LDH in the postoperative period (P<0.5). At 24h post-cardiopulmonary bypass, there were positive associations between LDH and IL-1ß (P<0.05), LDH and TNF-α (P<0.01), haptoglobin and TNF-α (P<0.05), and LDH and TNF-α (P<0.01) in G1, and between LDH and IL-6 (P<0.01), LDH and TNF-α (P<0.01), and LDH and IL-6 (P<0.01) in G2. Conclusion: There were no significant between-group differences in markers of hemolysis or inflammation. IL-6 and TNF-α were positively associated with duration of cardiopulmonary bypass in G1, while LDH was positively associated with duration of cardiopulmonary bypass in G2. The rate of significant associations between markers of hemolysis and inflammation was higher in the roller pump group (G1). Registration number: ReBEC (RBR-92b9dg). (AU)

• Processo FAPESP: 10/51874-2 - Análise comparativo da incidência de hemólise e resposta inflamatória sistêmica induzida pela circulação extracorpórea em bombas de rolete e em bomba centrífuga no perioperatório de revascularização de miocárdio
• Beneficiário: Marcos Augusto de Moraes Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular