Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Autor(es)

Dos Santos Ramos, Matheus Aparecido ^[1] ; Da Silva, Patricia Bento ^[2] ; Sposito, Larissa ^[1] ; De Toledo, Luciani Gaspar ^[1] ; Bonifacio, Bruna Vidal ^[1] ; Rodero, Camila Fernanda ^[2] ; Dos Santos, Karen Cristina ^[2] ; Chorilli, Marlus ^[2] ; Bauab, Tais Maria ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biol Sci, Campus Araraquara, Rodovia Araraquara Jau, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Campus Araraquara, Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF NANOMEDICINE; v. 13, p. 1179-1213, 2018.
• Citações Web of Science: 20

Resumo

Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms. (AU)

• Processo FAPESP: 16/08559-5 - Análise química e prospecção terapêutica de Syngonanthus nitens (Bong.) Ruhland e Cymbopogon nardus (L.) Rendle incorporados em sistemas nanotecnológicos aplicados ao tratamento da candidíase vulvovaginal
• Beneficiário: Taís Maria Bauab
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/24626-9 - Syngonanthus nitens (Bong.) Ruhland: prospecção químico-biológica do extrato metanólico de escapos no tratamento da candidíase vulvovaginal.
• Beneficiário: Matheus Aparecido dos Santos Ramos
• Modalidade de apoio: Bolsas no Brasil - Doutorado