Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Author(s)

Dos Santos Ramos, Matheus Aparecido ^[1] ; Da Silva, Patricia Bento ^[2] ; Sposito, Larissa ^[1] ; De Toledo, Luciani Gaspar ^[1] ; Bonifacio, Bruna Vidal ^[1] ; Rodero, Camila Fernanda ^[2] ; Dos Santos, Karen Cristina ^[2] ; Chorilli, Marlus ^[2] ; Bauab, Tais Maria ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biol Sci, Campus Araraquara, Rodovia Araraquara Jau, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Campus Araraquara, Araraquara, SP - Brazil

• Document type: Review article
• Source: INTERNATIONAL JOURNAL OF NANOMEDICINE; v. 13, p. 1179-1213, 2018.
• Web of Science Citations: 20

Abstract

Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms. (AU)

• FAPESP's process: 16/08559-5 - Chemical analyze and therapeutic prospection of Syngonanthus nitens (Bong.) Ruhland and Cymbopogon nardus (L.) Rendle loaded into nanotechnological systems applied to vulvovaginal candidiasis treatment
• Grantee: Taís Maria Bauab
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/24626-9 - Syngonanthus nitens (Bong.) Ruhland: prospection chemico-biologic of methanolic extract of scapes in the treatment of vuvlvovaginal candidiasis.
• Grantee: Matheus Aparecido dos Santos Ramos
• Support Opportunities: Scholarships in Brazil - Doctorate