Polymorphisms in Nonamelogenin Enamel Matrix Genes Are Associated with Dental Fluorosis

Autor(es)

Kuchler, Erika Calvano ^[1] ; Bruzamolin, Carolina Dea ^[2] ; Omori, Marjorie Ayumi ^[1] ; Costa, Marcelo C. ^[3] ; Antunes, Leonardo Santos ^[4] ; Pecharki, Giovana Daniela ^[5] ; Trevilatto, Paula Cristina ^[6] ; Vieira, Alexandre Rezende ^[7] ; Brancher, Joao Armando ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ave Cafe S-N, BR-14040904 Ribeirao Preto, SP - Brazil

^[2] Positivo Univ, Dept Dent, Rua Prof Pedro Viriato Parigot Souza 5300, BR-80740050 Curitiba, Parana - Brazil

^[3] Univ Fed Rio de Janeiro, Sch Dent, Dept Pediat Dent & Orthodont, Rio De Janeiro - Brazil

^[4] Fluminense Fed Univ, Sch Dent, Dept Specif Format, Niteroi, RJ - Brazil

^[5] Univ Fed Parana, Dept Community Hlth, Curitiba, Parana - Brazil

^[6] Pontificia Univ Catolica Parana PUCPR, Ctr Hlth & Biol Sci, Curitiba, Parana - Brazil

^[7] Univ Pittsburgh, Dept Oral Biol, Pittsburgh, PA - USA

• Tipo de documento: Artigo Científico
• Fonte: Caries Research; v. 52, n. 1-2, p. 1-6, 2018.
• Citações Web of Science: 6

Resumo

The aim of this study was to evaluate whether genetic polymorphisms in AMELX, AMBN, ENAM, TFIP11, and TUFT1 genes are associated with dental fluorosis (DF). A total of 1,017 children from 2 Brazilian cohorts were evaluated. These populations lived in cities with fluoridation of public water supplies. DF was assessed in erupted permanent teeth using the modified Dean index. The polymorphisms rs946252, rs12640848, rs4694075, rs5997096, and rs4970957 were analyzed by real-time PCR from genomic DNA. Associations between DF, genotype, and allele distribution were evaluated using the chi(2) test, with an alpha of 5%. The polymorphisms rs4694075, rs5997096, and rs4970957 in AMBN, TFIP11, and TUFT1 were associated with DF (p < 0.05). In conclusion, enamel matrix genes are associated with DF. (C) 2017 S. Karger AG, Basel (AU)

• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores