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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Brain diffusion tensor MRI in systematic lupus erythematosus: A systematic review

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Autor(es):
Costallat, Beatriz Lavras [1, 2] ; Ferreira, Daniel Miranda [3] ; Lapa, Aline Tamires [1, 4] ; Rittner, Leticia [1, 5] ; Lavras Costallat, Lilian Tereza [1, 6] ; Appenzeller, Simone [1, 6]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] State Univ Campinas UNICAMP, Lab Autoimmune Dis, Campinas, SP - Brazil
[2] State Univ Campinas UNICAMP, Fac Med Sci, Grad Program Internal Med, Campinas, SP - Brazil
[3] State Univ Campinas UNICAMP, Fac Med Sci, Dept Radiol, Campinas, SP - Brazil
[4] State Univ Campinas UNICAMP, Fac Med Sci, Grad Program Child & Adolescent Hlth, Campinas, SP - Brazil
[5] State Univ Campinas UNICAMP, Fac Elect & Comp Engn, Campinas, SP - Brazil
[6] State Univ Campinas UNICAMP, Fac Med Sci, Dept Med, Rheumatol Unit, Campinas, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: AUTOIMMUNITY REVIEWS; v. 17, n. 1, p. 36-43, JAN 2018.
Citações Web of Science: 7
Resumo

Diffusion tensor imaging (DTI) maps the brain's microstructure by measuring fractional anisotropy (FA) and mean diffusivity (MD). This systematic review describes brain diffusion tensor Magnetic resonance imaging (MRI) studies in systemic lupus erythematosus (SLE).The literature was reviewed following the PRISMA guidelines and using the terms ``lupus{''}, ``systemic lupus erythematosus{''}, ``SLE{''}, ``diffusion tensor imaging{''}, ``DTI{''}, ``white matter{''} (WM), ``microstructural damage{''}, ``tractography{''}, and ``fractional anisotropy{''}; the search included articles published in English from January 2007 to April 2017. The subjects included in the study were selected according to the ACR criteria and included 195 SLE patients with neuropsychiatric manifestation (NPSLE), 299 without neuropsychiatric manifestation (non-NPSLE), and 423 healthy controls (HC). Most studies identified significantly reduced FA and increased MD values in several WM regions of both NPSLE and non-NPSLE patients compared to HC. Subclinical microstructural changes were observed in either regional areas or the entire brain in both the non-NPSLE and NPSLE groups. (C) 2017 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 08/02917-0 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no lúpus eritematoso sistêmico
Beneficiário:Simone Appenzeller
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores