| Full text | |
| Author(s): |
Costallat, Beatriz Lavras
[1, 2]
;
Ferreira, Daniel Miranda
[3]
;
Lapa, Aline Tamires
[1, 4]
;
Rittner, Leticia
[1, 5]
;
Lavras Costallat, Lilian Tereza
[1, 6]
;
Appenzeller, Simone
[1, 6]
Total Authors: 6
|
| Affiliation: | [1] State Univ Campinas UNICAMP, Lab Autoimmune Dis, Campinas, SP - Brazil
[2] State Univ Campinas UNICAMP, Fac Med Sci, Grad Program Internal Med, Campinas, SP - Brazil
[3] State Univ Campinas UNICAMP, Fac Med Sci, Dept Radiol, Campinas, SP - Brazil
[4] State Univ Campinas UNICAMP, Fac Med Sci, Grad Program Child & Adolescent Hlth, Campinas, SP - Brazil
[5] State Univ Campinas UNICAMP, Fac Elect & Comp Engn, Campinas, SP - Brazil
[6] State Univ Campinas UNICAMP, Fac Med Sci, Dept Med, Rheumatol Unit, Campinas, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | AUTOIMMUNITY REVIEWS; v. 17, n. 1, p. 36-43, JAN 2018. |
| Web of Science Citations: | 7 |
| Abstract | |
Diffusion tensor imaging (DTI) maps the brain's microstructure by measuring fractional anisotropy (FA) and mean diffusivity (MD). This systematic review describes brain diffusion tensor Magnetic resonance imaging (MRI) studies in systemic lupus erythematosus (SLE).The literature was reviewed following the PRISMA guidelines and using the terms ``lupus{''}, ``systemic lupus erythematosus{''}, ``SLE{''}, ``diffusion tensor imaging{''}, ``DTI{''}, ``white matter{''} (WM), ``microstructural damage{''}, ``tractography{''}, and ``fractional anisotropy{''}; the search included articles published in English from January 2007 to April 2017. The subjects included in the study were selected according to the ACR criteria and included 195 SLE patients with neuropsychiatric manifestation (NPSLE), 299 without neuropsychiatric manifestation (non-NPSLE), and 423 healthy controls (HC). Most studies identified significantly reduced FA and increased MD values in several WM regions of both NPSLE and non-NPSLE patients compared to HC. Subclinical microstructural changes were observed in either regional areas or the entire brain in both the non-NPSLE and NPSLE groups. (C) 2017 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus |
| Grantee: | Simone Appenzeller |
| Support Opportunities: | Research Grants - Young Investigators Grants |