Improving the glial differentiation of human Schwann-like adipose-derived stem cells with graphene oxide substrates

Autor(es)

Verre, Andrea Francesco ^{[1, 2]} ; Faroni, Alessandro ^[3] ; Iliut, Maria ^{[1, 2]} ; Silva, Claudio ^{[4, 1, 2]} ; Muryn, Cristopher ^[5] ; Reid, Adam J. ^{[3, 6]} ; Vijayaraghavan, Aravind ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Manchester, Sch Mat, Manchester M13 9PL, Lancs - England

^[2] Univ Manchester, Natl Graphene Inst, Manchester M13 9PL, Lancs - England

^[3] Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Cell Matrix Biol & Regenerat Med, Blond McIndoe Labs, Sch Biol Sci, Fac Biol Med & Hl, Manchester M13 9PL, Lancs - England

^[4] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Sao Paulo - Brazil

^[5] Univ Manchester, Sch Chem, Manchester, Lancs - England

^[6] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Wythenshawe Hosp, Dept Plast Surg & Burns, Manchester, Lancs - England

• Tipo de documento: Artigo Científico
• Fonte: INTERFACE FOCUS; v. 8, n. 3 JUN 6 2018.
• Citações Web of Science: 3

Resumo

There is urgent need to improve the clinical outcome of peripheral nerve injury. Many efforts are directed towards the fabrication of bioengineered conduits, which could deliver stem cells to the site of injury to promote and guide peripheral nerve regeneration. The aim of this study is to assess whether graphene and related nanomaterials can be useful in the fabrication of such conduits. A comparison is made between graphene oxide (GO) and reduced GO substrates. Our results show that the graphene substrates are highly biocompatible, and the reduced GO substrates are more effective in increasing the gene expression of the biomolecules involved in the regeneration process compared to the other substrates studied. (AU)

• Processo FAPESP: 14/05048-4 - Materiais híbridos ternários de grafenos, polianilina e hexaniobatos: novos materiais para eletrodos supercapacitores
• Beneficiário: Claudio Hanashiro Barbosa Silva
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado