Structure/Activity of Pt-II/& IT;N & IT;,& IT;N & IT;-Disubstituted-& IT;N & IT;'-acylthiourea Complexes: Anti-Tumor and Anti-& IT;Mycobacterium tuberculosis & IT; Activities

Autor(es):Mostrar menos -

Plutin, Ana M. ^[1] ; Alvarez, Anislay ^[1] ; Mocelo, Raul ^[1] ; Ramos, Raul ^[1] ; Sanchez, Osmar C. ^[1] ; Castellano, Eduardo E. ^[2] ; da Silva, Monize M. ^[3] ; Villarreal, Wilmer ^[3] ; Colina-Vegas, Legna ^[3] ; Pavan, Fernando R. ^[4] ; Batista, Alzir A. ^[3]

Afiliação do(s) autor(es)

^[1] Univ La Habana, Fac Quim, Lab Sintesis Organ, Havana 10400 - Cuba

^[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-05508090 Sao Carlos, SP - Brazil

^[3] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

^[4] Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 29, n. 6, p. 1256-1267, JUN 2018.
• Citações Web of Science: 1

Resumo

The syntheses, characterization, cytotoxicity against tumor cells and anti-Mycobacterium tuberculosis activity assays of Pt-II/PPh3/N,N-disubstituted-N'-acylthioureas complexes with general formulae {[}Pt(PPh3)(2)(L)]PF6, PPh3 = triphenylphosphine; L = N,N-disubstituted-N'-acylthiourea, are here reported. The complexes were characterized by elemental analysis, molar conductivity, infrared (IR), nuclear magnetic resonance (NMR) (H-1, C-13[H-1] and P-31[H-1]) spectroscopy. The P-31[H-1] NMR data are consistent with the presence of two PPh 3 ligands cis to each other position, and one N,N-disubstituted-N'-acylthiourea coordinated to the metal through O and S, in a chelate form. The structures of the complexes were determined by X-ray crystallography, forming distorted square-planar structures. The complexes were tested in human cell lines carcinomas and also screened with respect to their anti-Mycobacterium tuberculosis activity (H37RvATCC 27294). It was found that complexes with N,N-disubstituted-N'-acylthiourea containing open and small chains as R2 groups show higher cytotoxic and higher anti-Mycobacterium tuberculosis activity than those containing rings in this position. (AU)

• Processo FAPESP: 14/10516-7 - Busca por complexos de rutênio (II), com propriedades quimioterapêuticas: avaliação de possíveis efeitos sinergísticos e possíveis mecanismo de ação
• Beneficiário: Alzir Azevedo Batista
• Modalidade de apoio: Auxílio à Pesquisa - Regular