| Full text | |
| Author(s): Show less - |
Plutin, Ana M.
[1]
;
Alvarez, Anislay
[1]
;
Mocelo, Raul
[1]
;
Ramos, Raul
[1]
;
Sanchez, Osmar C.
[1]
;
Castellano, Eduardo E.
[2]
;
da Silva, Monize M.
[3]
;
Villarreal, Wilmer
[3]
;
Colina-Vegas, Legna
[3]
;
Pavan, Fernando R.
[4]
;
Batista, Alzir A.
[3]
Total Authors: 11
|
| Affiliation: | [1] Univ La Habana, Fac Quim, Lab Sintesis Organ, Havana 10400 - Cuba
[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-05508090 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[4] Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 29, n. 6, p. 1256-1267, JUN 2018. |
| Web of Science Citations: | 1 |
| Abstract | |
The syntheses, characterization, cytotoxicity against tumor cells and anti-Mycobacterium tuberculosis activity assays of Pt-II/PPh3/N,N-disubstituted-N'-acylthioureas complexes with general formulae {[}Pt(PPh3)(2)(L)]PF6, PPh3 = triphenylphosphine; L = N,N-disubstituted-N'-acylthiourea, are here reported. The complexes were characterized by elemental analysis, molar conductivity, infrared (IR), nuclear magnetic resonance (NMR) (H-1, C-13[H-1] and P-31[H-1]) spectroscopy. The P-31[H-1] NMR data are consistent with the presence of two PPh 3 ligands cis to each other position, and one N,N-disubstituted-N'-acylthiourea coordinated to the metal through O and S, in a chelate form. The structures of the complexes were determined by X-ray crystallography, forming distorted square-planar structures. The complexes were tested in human cell lines carcinomas and also screened with respect to their anti-Mycobacterium tuberculosis activity (H37RvATCC 27294). It was found that complexes with N,N-disubstituted-N'-acylthiourea containing open and small chains as R2 groups show higher cytotoxic and higher anti-Mycobacterium tuberculosis activity than those containing rings in this position. (AU) | |
| FAPESP's process: | 14/10516-7 - Search for ruthenium (II) complexes, with chemotherapeutic properties: evaluation of possible sinergistic effects and possible action mechanism |
| Grantee: | Alzir Azevedo Batista |
| Support Opportunities: | Regular Research Grants |