Recent advancements in lactic acid production - a review

Autor(es)

Es, Ismail ^[1] ; Khaneghah, Amin Mousavi ^[2] ; Barba, Francisco J. ^[3] ; Saraiva, Jorge A. ^[4] ; Sant'Ana, Anderson S. ^[2] ; Bagher Hashemi, Seyed Mohammad ^[5]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Sch Chem Engn, Dept Mat & Bioproc Engn, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Dept Food Sci, Fac Food Engn, Campinas, SP - Brazil

^[3] Univ Valencia, Food Sci Toxicol & Forens Med Dept, Nutr & Food Sci Area, Fac Pharm, Prevent Med & Publ Hlth, Avda Vicent Andres Estelles S-N, E-46100 Valencia - Spain

^[4] Univ Aveiro, Dept Quim, QOPNA, Campus Univ Santiago, P-3810193 Aveiro - Portugal

^[5] Fasa Univ, Food Sci & Technol Dept, Coll Agr, Fasa - Iran

• Tipo de documento: Artigo de Revisão
• Fonte: Food Research International; v. 107, p. 763-770, MAY 2018.
• Citações Web of Science: 21

Resumo

Lactic acid, as an organic acid, has essential roles in industrial applications ranging from the food industry to life-sciences. Conventional fermentation methods have been well-studied since late 18th century, but are unable to achieve consumers' expectations regarding both quality and quantity. Therefore, novel technological developments of lactic acid production to increase yield and decrease over-all cost have become the primary goal. Genetic and metabolic engineering are great tools to overcome problems associated with product inhibition, undesired by-product formation, the negative effect of extreme culture conditions and most importantly inefficient use of expensive substrates. Adaptation of immobilization techniques to large-scale production can enhance fermentation yield. Moreover, improving novel techniques such as cell recycle systems, and simultaneous saccharification will lead engineered microorganisms to produce lactic acid with increased concentration, yield, and productivity. The present study reviews the viability and industrial potentiality of the most recent advances in the biotechnological production of lactic acid. (AU)

• Processo FAPESP: 15/14468-0 - SISTEMAS MICROFLUÍDICOS PARA A INCORPORAÇÃO DE SMALL INTERFERING RNA (siRNA) EM LIPOSSOMAS CATIÔNICOS E PARA TRANSFECÇÃO IN VITRO DE CÉLULAS DE MAMÍFEROS DESTINADOS À TERAPIA GÊNICA
• Beneficiário: Ismail Es
• Modalidade de apoio: Bolsas no Brasil - Doutorado