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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Recent advancements in lactic acid production - a review

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Author(s):
Es, Ismail [1] ; Khaneghah, Amin Mousavi [2] ; Barba, Francisco J. [3] ; Saraiva, Jorge A. [4] ; Sant'Ana, Anderson S. [2] ; Bagher Hashemi, Seyed Mohammad [5]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Sch Chem Engn, Dept Mat & Bioproc Engn, Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Dept Food Sci, Fac Food Engn, Campinas, SP - Brazil
[3] Univ Valencia, Food Sci Toxicol & Forens Med Dept, Nutr & Food Sci Area, Fac Pharm, Prevent Med & Publ Hlth, Avda Vicent Andres Estelles S-N, E-46100 Valencia - Spain
[4] Univ Aveiro, Dept Quim, QOPNA, Campus Univ Santiago, P-3810193 Aveiro - Portugal
[5] Fasa Univ, Food Sci & Technol Dept, Coll Agr, Fasa - Iran
Total Affiliations: 5
Document type: Review article
Source: Food Research International; v. 107, p. 763-770, MAY 2018.
Web of Science Citations: 21
Abstract

Lactic acid, as an organic acid, has essential roles in industrial applications ranging from the food industry to life-sciences. Conventional fermentation methods have been well-studied since late 18th century, but are unable to achieve consumers' expectations regarding both quality and quantity. Therefore, novel technological developments of lactic acid production to increase yield and decrease over-all cost have become the primary goal. Genetic and metabolic engineering are great tools to overcome problems associated with product inhibition, undesired by-product formation, the negative effect of extreme culture conditions and most importantly inefficient use of expensive substrates. Adaptation of immobilization techniques to large-scale production can enhance fermentation yield. Moreover, improving novel techniques such as cell recycle systems, and simultaneous saccharification will lead engineered microorganisms to produce lactic acid with increased concentration, yield, and productivity. The present study reviews the viability and industrial potentiality of the most recent advances in the biotechnological production of lactic acid. (AU)

FAPESP's process: 15/14468-0 - MICROFLUIDIC SYSTEMS FOR INCORPORATION OF SMALL INTERFERING RNA (siRNA) IN CATIONIC LIPOSOMES AND FOR IN VITRO ANIMAL CELL TRANSFECTION TARGETING GENE THERAPY
Grantee:Ismail Es
Support Opportunities: Scholarships in Brazil - Doctorate