| Texto completo | |
| Autor(es): |
Trino, Luciana D.
[1]
;
Bronze-Uhle, Erika S.
[1]
;
Ramachandran, Amsaveni
[2]
;
Lisboa-Filho, Paulo N.
[1]
;
Mathew, Mathew T.
[3]
;
George, Anne
[2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ, UNESP, Sch Sci, BR-17033360 Bauru, SP - Brazil
[2] Univ Illinois, Coll Dent, Dept Oral Biol, Chicago, IL 60612 - USA
[3] Univ Illinois, Sch Med Rockford, Coll Med Rockford, Dept Biomed Sci, Rockford, IL 61107 - USA
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS; v. 81, p. 26-38, MAY 2018. |
| Citações Web of Science: | 2 |
| Resumo | |
Titanium (Ti) is widely used in biomedical devices due to its recognized biocompatibility. However, implant failures and subsequent clinical side effects are still recurrent. In this context, improvements can be achieved by designing biomaterials where the bulk and the surface of Ti are independently tailored. The conjugation of biomolecules onto the Ti surface can improve its bioactivity, thus accelerating the osteointegration process. Ti was modified with TiO2, two different spacers, 3-(4-aminophenyl) propionic acid (APPA) or 3-mercaptopropionic acid (MPA) and dentin matrix protein 1 (DMP1) peptides. X-ray photoelectron spectroscopy analysis revealed the presence of carbon and nitrogen for all samples, indicating a success in the functionalization process. Furthermore, DMP1 peptides showed an improved coverage area for the samples with APPA and MPA spacers. Biological tests indicated that the peptides could modulate cell affinity, proliferation, and differentiation. Enhanced results were observed in the presence of MPA. Moreover, the immobilization of DMP1 peptides through the spacers led to the formation of calcium phosphate minerals with a Ca/P ratio near to that of hydroxyapatite. Corrosion and tribocorrosion results indicated an increased resistance to corrosion and lower mass loss in the functionalized materials, showing that this new type of functional material has attractive properties for biomaterials application. (AU) | |
| Processo FAPESP: | 14/01713-3 - Funcionalização de superfícies e estudo de adsorção em óxidos metálicos |
| Beneficiário: | Luciana Daniele Trino Albano |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 14/27015-0 - Estudo da adesão de proteínas em filmes finos de óxidos metálicos |
| Beneficiário: | Luciana Daniele Trino Albano |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |
| Processo FAPESP: | 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais |
| Beneficiário: | Elson Longo da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 14/20471-0 - Filmes finos de óxidos metálicos funcionalizados para estudo da adsorção de proteínas |
| Beneficiário: | Paulo Noronha Lisboa Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |