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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Titanium surface bio-functionalization using osteogenic peptides: Surface chemistry, biocompatibility, corrosion and tribocorrosion aspects

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Trino, Luciana D. [1] ; Bronze-Uhle, Erika S. [1] ; Ramachandran, Amsaveni [2] ; Lisboa-Filho, Paulo N. [1] ; Mathew, Mathew T. [3] ; George, Anne [2]
Total Authors: 6
[1] Sao Paulo State Univ, UNESP, Sch Sci, BR-17033360 Bauru, SP - Brazil
[2] Univ Illinois, Coll Dent, Dept Oral Biol, Chicago, IL 60612 - USA
[3] Univ Illinois, Sch Med Rockford, Coll Med Rockford, Dept Biomed Sci, Rockford, IL 61107 - USA
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 2

Titanium (Ti) is widely used in biomedical devices due to its recognized biocompatibility. However, implant failures and subsequent clinical side effects are still recurrent. In this context, improvements can be achieved by designing biomaterials where the bulk and the surface of Ti are independently tailored. The conjugation of biomolecules onto the Ti surface can improve its bioactivity, thus accelerating the osteointegration process. Ti was modified with TiO2, two different spacers, 3-(4-aminophenyl) propionic acid (APPA) or 3-mercaptopropionic acid (MPA) and dentin matrix protein 1 (DMP1) peptides. X-ray photoelectron spectroscopy analysis revealed the presence of carbon and nitrogen for all samples, indicating a success in the functionalization process. Furthermore, DMP1 peptides showed an improved coverage area for the samples with APPA and MPA spacers. Biological tests indicated that the peptides could modulate cell affinity, proliferation, and differentiation. Enhanced results were observed in the presence of MPA. Moreover, the immobilization of DMP1 peptides through the spacers led to the formation of calcium phosphate minerals with a Ca/P ratio near to that of hydroxyapatite. Corrosion and tribocorrosion results indicated an increased resistance to corrosion and lower mass loss in the functionalized materials, showing that this new type of functional material has attractive properties for biomaterials application. (AU)

FAPESP's process: 14/01713-3 - Functionalization and adsorption studies on thin oxide films
Grantee:Luciana Daniele Trino
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/20471-0 - Functionalized metal oxides thin films for the study of protein adsorption
Grantee:Paulo Noronha Lisboa Filho
Support type: Regular Research Grants
FAPESP's process: 13/07296-2 - CDMF - Center for the Development of Functional Materials
Grantee:Elson Longo da Silva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/27015-0 - Protein adhesion study in metal oxides thin films
Grantee:Luciana Daniele Trino
Support type: Scholarships abroad - Research Internship - Doctorate