| Grant number: | 14/01713-3 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | July 01, 2014 |
| End date: | April 30, 2018 |
| Field of knowledge: | Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials |
| Agreement: | Coordination of Improvement of Higher Education Personnel (CAPES) |
| Principal Investigator: | Paulo Noronha Lisboa Filho |
| Grantee: | Luciana Daniele Trino Albano |
| Host Institution: | Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil |
| Associated research grant: | 13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID |
| Associated scholarship(s): | 14/27015-0 - Protein adhesion study in metal oxides thin films, BE.EP.DR |
Abstract This proposal is inserted into a multidisciplinary context, as a part of the new subject of nanobiotechnology. Nanostructured metal oxides (TiO2 and ZnO) have been used as surface modifiers in medical implants, promoting improvements in the material biocorrosion and increased oxides bioactivity, which indicates promising results in the interaction with living tissues. Despite of recognized biocompatibility of these oxides, there still are many aspects of the mechanisms of adhesion between the proteins and the metal oxides surfaces. Different in vitro and in vivo tests demonstrate that the biocompatibility and biocorrosion properties depend on the composition, thickness, homogeneity and porosity of the oxide. Chemically, the surface of such oxides are mainly terminated by -OH groups which can be readily functionalized. This chemical functionalization or simply a physical change in the material surface can improve the interaction of the oxide with the biological environment. This project proposes to improve understanding of the mechanisms of adsorption of proteins on different structures of metal oxides. The aim of this study was to evaluate the physicochemical and thermodynamic parameters, in order to better analyze the interaction and adsorption of protein to metal surface, since different biomedical applications require different properties of protein -oxide interaction. Different strategies for functionalization and adsorption will be studied and tested in biological systems. (AU) | |
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