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Functionalization and adsorption studies on thin oxide films

Grant number: 14/01713-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2014
Effective date (End): April 30, 2018
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Paulo Noronha Lisboa Filho
Grantee:Luciana Daniele Trino Albano
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
Associated research grant:13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID
Associated scholarship(s):14/27015-0 - Protein adhesion study in metal oxides thin films, BE.EP.DR


This proposal is inserted into a multidisciplinary context, as a part of the new subject of nanobiotechnology. Nanostructured metal oxides (TiO2 and ZnO) have been used as surface modifiers in medical implants, promoting improvements in the material biocorrosion and increased oxides bioactivity, which indicates promising results in the interaction with living tissues. Despite of recognized biocompatibility of these oxides, there still are many aspects of the mechanisms of adhesion between the proteins and the metal oxides surfaces. Different in vitro and in vivo tests demonstrate that the biocompatibility and biocorrosion properties depend on the composition, thickness, homogeneity and porosity of the oxide. Chemically, the surface of such oxides are mainly terminated by -OH groups which can be readily functionalized. This chemical functionalization or simply a physical change in the material surface can improve the interaction of the oxide with the biological environment. This project proposes to improve understanding of the mechanisms of adsorption of proteins on different structures of metal oxides. The aim of this study was to evaluate the physicochemical and thermodynamic parameters, in order to better analyze the interaction and adsorption of protein to metal surface, since different biomedical applications require different properties of protein -oxide interaction. Different strategies for functionalization and adsorption will be studied and tested in biological systems. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TRINO, LUCIANA D.; DIAS, LEONARDO F. G.; ALBANO, LUIZ G. S.; BRONZE-UHLE, ERIKA S.; RANGEL, ELIDIANE C.; GRAEFF, CARLOS F. O.; LISBOA-FILHO, PAULO N.. Zinc oxide surface functionalization and related effects on corrosion resistance of titanium implants. CERAMICS INTERNATIONAL, v. 44, n. 4, p. 4000-4008, . (14/20471-0, 14/01713-3, 13/09963-6, 13/07296-2)
BRONZE-UHLE, ERIKA S.; DIAS, LEONARDO F. G.; TRINO, LUCIANA D.; MATOS, ADRIANA A.; DE OLIVEIRA, RODRIGO C.; LISBOA-FILHO, PAULO N.. Physicochemical characterization of albumin immobilized on different TiO2 surfaces for use in implant materials. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 564, p. 39-50, . (14/01713-3, 14/20471-0, 16/11183-7, 17/15035-5)
BRONZE-UHLE, ERIKA S.; DIAS, LEONARDO F. G.; TRINO, LUCIANA D.; MATOS, ADRIANA A.; DE OLIVEIRA, RODRIGO C.; LISBOA-FILHO, PAULO N.. Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application. SURFACE & COATINGS TECHNOLOGY, v. 357, p. 36-47, . (14/01713-3, 14/20471-0, 16/11183-7, 17/15035-5)
TRINO, LUCIANA D.; ALBANO, LUIZ G. S.; BRONZE-UHLE, ERIKA S.; GEORGE, ANNE; MATHEW, MATHEW T.; LISBOA-FILHO, PAULO N.. Physicochemical, osteogenic and corrosion properties of bio-functionalized ZnO thin films: Potential material for biomedical applications. CERAMICS INTERNATIONAL, v. 44, n. 17, p. 21004-21014, . (14/01713-3, 13/07296-2, 13/09963-6, 14/27015-0, 17/15035-5)
SIMAO ALBANO, LUIZ GUSTAVO; PAULIN, JOAO VITOR; TRINO, LUCIANA DANIELE; FERNANDES, SILVIA LETICIA; DE OLIVEIRA GRAEFF, CARLOS FREDERICO. Ultraviolet-protective thin film based on PVA-melanin/rod-coated silver nanowires and its application as a transparent capacitor. Journal of Applied Polymer Science, v. 136, n. 30, . (14/01713-3, 17/11072-3, 13/07296-2, 15/23000-1, 13/09963-6)
TRINO, LUCIANA D.; BRONZE-UHLE, ERIKA S.; GEORGE, ANNE; MATHEW, MATHEW T.; LISBOA-FILHO, PAULO N.. Surface Physicochemical and Structural Analysis of Functionalized Titanium Dioxide Films. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 546, p. 168-178, . (13/07296-2, 14/01713-3, 14/20471-0, 14/27015-0)
TRINO, LUCIANA D.; BRONZE-UHLE, ERIKA S.; RAMACHANDRAN, AMSAVENI; LISBOA-FILHO, PAULO N.; MATHEW, MATHEW T.; GEORGE, ANNE. Titanium surface bio-functionalization using osteogenic peptides: Surface chemistry, biocompatibility, corrosion and tribocorrosion aspects. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 81, p. 26-38, . (13/07296-2, 14/01713-3, 14/20471-0, 14/27015-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ALBANO, Luciana Daniele Trino. Surface functionalization and biomolecules attachment study upon metallic oxides. 2018. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências. Bauru Bauru.

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