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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Advanced data mining approaches in the assessment of urinary concentrations of bisphenols, chlorophenols, parabens and benzophenones in Brazilian children and their association to DNA damage

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Autor(es):
Rocha, Bruno A. [1, 2, 3] ; Asimakopoulos, Alexandros G. [1, 2, 4] ; Honda, Masato [1, 2] ; da Costa, Nattane L. [5] ; Barbosa, Rommel M. [5] ; Barbosa, Jr., Fernando [3] ; Kannan, Kurunthachalam [1, 2, 6]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] SUNY Albany, Wadsworth Ctr, New York State Dept Hlth, Albany, NY 12201 - USA
[2] SUNY Albany, Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY 12201 - USA
[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Lab Toxicol & Essencialidade Met, BR-14040903 Ribeirao Preto, SP - Brazil
[4] Norwegian Univ Sci & Technol NTNU, Dept Chem, N-7491 Trondheim - Norway
[5] Univ Fed Goias, Inst Informat, BR-74690900 Goiania, Go - Brazil
[6] King Abdulaziz Univ, Fac Sci, Biochem Dept, Jeddah - Saudi Arabia
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Environment International; v. 116, p. 269-277, JUL 2018.
Citações Web of Science: 12
Resumo

Human exposure to endocrine disrupting chemicals (EDCs) has received considerable attention over the last three decades. However, little is known about the influence of co-exposure to multiple EDCs on effect-biomarkers such as oxidative stress in Brazilian children. In this study, concentrations of 40 EDCs were determined in urine samples collected from 300 Brazilian children of ages 6-14 years and data were analyzed by advanced data mining techniques. Oxidative DNA damage was evaluated from the urinary concentrations of 8-hydroxy-2'-deoxyguanosine (8OHDG). Fourteen EDCs, including bisphenol A (BPA), methyl paraben (MeP), ethyl paraben (EtP), propyl paraben (PrP), 3,4-dihydroxy benzoic acid (3,4-DHB), methyl-protocatechuic acid (OH-MeP), ethyl-protocatechuic acid (OH-EtP), triclosan (TCS), triclocarban (TCC), 2-hydroxy-4-methoxybenzophenone (BP3), 2,4-dihydroxybenzophenone (BP1), bisphenol A bis(2,3-dihydroxypropyl) glycidyl ether (BADGE center dot 2H(2)O), 2,4-dichlorophenol (2,4-DCP), and 2,5-dichlorophenol (2,5-DCP) were found in> 50% of the urine samples analyzed. The highest geometric mean concentrations were found for MeP (43.1 ng/mL), PrP (3.12 ng/mL), 3,4-DHB (42.2 ng/mL), TCS (8.26 ng/mL), BP3 (3.71 ng/mL), and BP1 (4.85 ng/mL), and exposures to most of which were associated with personal care product (PCP) use. Statistically significant associations were found between urinary concentrations of 8OHDG and BPA, MeP, 3,4-DHB, OH-MeP, OH-EtP, TCS, BP3, 2,4-DCP, and 2,5-DCP. After clustering the data on the basis of i) 14 EDCs (exposure levels), ii) demography (age, gender and geographic location), and iii) 8OHDG (effect), two distinct clusters of samples were identified. 8OHDG concentration was the most critical parameter that differentiated the two clusters, followed by OH-EtP. When 8OHDG was removed from the dataset, predictability of exposure variables increased in the order of: OHEtP > OH-MeP > 3,4-DHB > BPA > 2,4-DCP > MeP > TCS > EtP > BP1 > 2,5-DCP. Our results showed that co-exposure to OH-EtP, OH-MeP, 3,4-DHB, BPA, 2,4-DCP, MeP, TCS, EtP, BP1, and 2,5-DCP was associated with DNA damage in children. This is the first study to report exposure of Brazilian children to a wide range of EDCs and the data mining approach further strengthened our findings of chemical co-exposures and biomarkers of effect. (AU)

Processo FAPESP: 15/20928-3 - Determinação de biomarcadores urinários para avaliação da exposição de crianças brasileiras a disruptores endócrinos: bisfenóis, parabenos e ftalatos
Beneficiário:Bruno Alves Rocha
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
Processo FAPESP: 13/23710-3 - Uso da espectroscopia Shpol'skii e LC-MS/MS para a determinação do bisfenol A e análogos em amostras de urina e avaliação da exposição em crianças residentes no estado de São Paulo
Beneficiário:Bruno Alves Rocha
Linha de fomento: Bolsas no Brasil - Pós-Doutorado