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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Input Convergence, Synaptic Plasticity and Functional Coupling Across Hippocampal-Prefrontal-Thalamic Circuits

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Autor(es):
Bueno-Junior, Lezio S. [1] ; Leite, Joao P. [1]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, Ribeirao Preto - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: FRONTIERS IN NEURAL CIRCUITS; v. 12, MAY 23 2018.
Citações Web of Science: 2
Resumo

Executive functions and working memory are long known to involve the prefrontal cortex (PFC), and two PFC-projecting areas: midline/paramidline thalamus (MLT) and cornus ammonis 1 (CA1)/subiculum of the hippocampal formation (HF). An increasing number of rodent electrophysiology studies are examining these substrates together, thus providing circuit-level perspectives on input convergence, synaptic plasticity and functional coupling, as well as insights into cognition mechanisms and brain disorders. Our review article puts this literature into a method-oriented narrative. As revisited throughout the text, limbic thalamic and hippocampal afferents to the PFC gate one another's inputs, which in turn are modulated by PFC interneurons and ascending monoaminergic projections. In addition, long-term synaptic plasticity, paired-pulse facilitation (PPF), and event-related potentials (ERP) dynamically vary across PFC-related circuits during learning paradigms and drug effects. Finally, thalamic-prefrontal loops, which have been shown to amplify both cognitive processes and limbic seizures, are also being implicated as relays in the prefrontal-hippocampal feedback, contributing to spatial navigation and decision making. Based on these issues, we conclude the review with a critical synthesis and some research directions. (AU)

Processo FAPESP: 12/06123-4 - Plasticidade sináptica hipocampo-pré-frontal em ratos acordados: efeitos da estimulação talâmica durante o sono natural e implicações para a consolidação de memórias
Beneficiário:Lézio Soares Bueno Júnior
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/17882-4 - Epilepsias farmacorresistentes: desafios diagnósticos, estudo das comorbidades associadas e novas abordagens experimentais
Beneficiário:João Pereira Leite
Linha de fomento: Auxílio à Pesquisa - Temático