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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Input Convergence, Synaptic Plasticity and Functional Coupling Across Hippocampal-Prefrontal-Thalamic Circuits

Full text
Author(s):
Bueno-Junior, Lezio S. [1] ; Leite, Joao P. [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, Ribeirao Preto - Brazil
Total Affiliations: 1
Document type: Review article
Source: FRONTIERS IN NEURAL CIRCUITS; v. 12, MAY 23 2018.
Web of Science Citations: 2
Abstract

Executive functions and working memory are long known to involve the prefrontal cortex (PFC), and two PFC-projecting areas: midline/paramidline thalamus (MLT) and cornus ammonis 1 (CA1)/subiculum of the hippocampal formation (HF). An increasing number of rodent electrophysiology studies are examining these substrates together, thus providing circuit-level perspectives on input convergence, synaptic plasticity and functional coupling, as well as insights into cognition mechanisms and brain disorders. Our review article puts this literature into a method-oriented narrative. As revisited throughout the text, limbic thalamic and hippocampal afferents to the PFC gate one another's inputs, which in turn are modulated by PFC interneurons and ascending monoaminergic projections. In addition, long-term synaptic plasticity, paired-pulse facilitation (PPF), and event-related potentials (ERP) dynamically vary across PFC-related circuits during learning paradigms and drug effects. Finally, thalamic-prefrontal loops, which have been shown to amplify both cognitive processes and limbic seizures, are also being implicated as relays in the prefrontal-hippocampal feedback, contributing to spatial navigation and decision making. Based on these issues, we conclude the review with a critical synthesis and some research directions. (AU)

FAPESP's process: 12/06123-4 - Hippocampal-prefrontal synaptic plasticity in awake rats: effects of thalamic stimulation during natural sleep and implications for memory consolidation
Grantee:Lézio Soares Bueno Júnior
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/17882-4 - Drug-resistant epilepsies: diagnostic challenges, associated comorbidities and new experimental approaches
Grantee:João Pereira Leite
Support Opportunities: Research Projects - Thematic Grants