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THE EFFECTS OF SENSORY TRAINING ON PAIN MODULATION, COGNITION AND TIME TO FATIGUE IN HEALTHY ADULTS.

Grant number: 16/06459-3
Support Opportunities:Scholarships in Brazil - Doctorate
Start date: July 01, 2016
End date: January 31, 2020
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Felipe Fregni
Grantee:Fabiana Tenório Gomes da Silva
Host Institution: Instituto de Medicina Física e de Reabilitação (IMREA-HCFMUSP). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Pain can be modulated by different factors, such as sensory processing and plasticity. Evidence has shown that plasticity of primary sensorial neurons can induce neuroplasticity changes over the somatosensory networks, changing the subsequent responsiveness of those systems, in a state dependent manner. Moreover, the processing of nociceptor inputs from the afferent pathways can change the synaptic efficacy and excitability in the nociceptive pathways, which can ultimately induce changes in pain sensitivity. Therefore, it may be possible to centrally modify an individual´s pain perception in response to passive sensory experience, especially by sensory training. Median nerve stimulation (MNS) is a form of peripheral sensorial stimulation that is able to change the activity in the central nervous system (CNS). It is thought that the sensorial information driven by peripheral stimulation of the afferent pathways (i.e. spinothalamic and potentially the spinoreticular tracts) is relayed to the cortex through the thalamic nuclei. This type of sensorial stimulation has been thought to change brain activity based on a co-activation mechanism. The hypothesis underlying this assumption is that according to the Hebbian principle of plasticity, sensorial stimulation will induce a firing synchronization across the afferent neural pathway. Once it reaches the thalamic nuclei, sensorial information will then be relayed to the cortex by a pacemaker system that is able to generate and synchronize activity through thalamocortical circuitries. This co-activation mechanism hypothesis has been supported by neuroimaging data, in which activation of the primary and secondary somatosensory areas, as well as the insula, has been demonstrated following sensorial stimulation.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Fabiana Tenório Gomes da. Neurophysiological and clinical effects associated to the median nerve stimulation combined with physical exercise on experimental pain in sedentary individuals: a randomized double-blind study. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Psicologia (IP/SBD) São Paulo.