| Texto completo | |
| Autor(es): |
Da Broi, Michele G.
[1]
;
Jordao-, Jr., Alceu A.
[2]
;
Ferriani, Rui A.
[1, 3]
;
Navarro, Paula A.
[1, 3]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Obstet & Gynecol, Human Reprod Div, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Nutr & Metab Lab, Sao Paulo - Brazil
[3] CNPq, Natl Inst Hormones & Womans Hlth, Porto Alegre, RS - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Molecular Reproduction and Development; v. 85, n. 2, p. 128-136, FEB 2018. |
| Citações Web of Science: | 8 |
| Resumo | |
Early endometriosis is associated with infertility, and oxidative stress may play a role in the pathogenesis of disease-related infertility. This prospective case-control study aimed to compare the presence of oxidative stress markers in the follicular microenvironment and systemic circulation of infertile women with minimal/mild endometriosis (EI/II) versus individuals undergoing controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI). Seventy-one blood samples (27 from infertile women with EI/II and 44 controls with tubal and/or male infertility factor) and 51 follicular fluid samples (19 EI/II and 32 controls) were obtained on the day of oocyte retrieval. Total hydroperoxides (FOX1), reduced glutathione, vitamin E, Superoxide dismutase, total antioxidant capacity, malondialdehyde, advanced oxidation protein products, and 8-hydroxy-2-deoxyguanosine (8OHdG) concentrations were measured in both fluids. Women with EI/II showed higher FOX1 (8.48 +/- 1.72 vs. 7.69 +/- 1.71mol/g protein) and lower total antioxidant capacity (0.38 +/- 0.18 vs. 0.46 +/- 0.15mEq Trolox/L) concentrations in serum, and higher 8OHdG concentrations (24.21 +/- 8.56 vs. 17.22 +/- 5.6ng/ml) in follicular fluid compared with controls. These data implicate both systemic and follicular oxidative stress may in infertile women with EI/II undergoing controlled ovarian stimulation for ICSI. Furthermore, the elevated 8OHdG concentrations in follicular fluid of women with EI/II may be related to compromised oocyte quality. (AU) | |
| Processo FAPESP: | 14/15866-6 - Annual Meeting of the American Society for Reproductive Medicine - ASRM2014 |
| Beneficiário: | Paula Andrea de Albuquerque Salles Navarro |
| Modalidade de apoio: | Auxílio à Pesquisa - Reunião - Exterior |
| Processo FAPESP: | 08/58197-6 - Balanço oxidante e antioxidante de mulheres inférteis com endometriose comparadas a controle (fatores masculino e tubário de infertilidade) submetidas a estimulação ovariana e influência nos resultados |
| Beneficiário: | Paula Andrea de Albuquerque Salles Navarro |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 08/56373-1 - Avaliacao da peroxidacao lipidica, dos niveis de vitamina e e da capacidade antioxidante total no soro de mulheres inferteis com endometriose e infertilidade por fatores tubario e masculino e assoc.. |
| Beneficiário: | Rafaela Lopes Cardoso |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |