| Full text | |
| Author(s): |
Da Broi, Michele G.
[1]
;
Jordao-, Jr., Alceu A.
[2]
;
Ferriani, Rui A.
[1, 3]
;
Navarro, Paula A.
[1, 3]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Obstet & Gynecol, Human Reprod Div, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Nutr & Metab Lab, Sao Paulo - Brazil
[3] CNPq, Natl Inst Hormones & Womans Hlth, Porto Alegre, RS - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Molecular Reproduction and Development; v. 85, n. 2, p. 128-136, FEB 2018. |
| Web of Science Citations: | 8 |
| Abstract | |
Early endometriosis is associated with infertility, and oxidative stress may play a role in the pathogenesis of disease-related infertility. This prospective case-control study aimed to compare the presence of oxidative stress markers in the follicular microenvironment and systemic circulation of infertile women with minimal/mild endometriosis (EI/II) versus individuals undergoing controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI). Seventy-one blood samples (27 from infertile women with EI/II and 44 controls with tubal and/or male infertility factor) and 51 follicular fluid samples (19 EI/II and 32 controls) were obtained on the day of oocyte retrieval. Total hydroperoxides (FOX1), reduced glutathione, vitamin E, Superoxide dismutase, total antioxidant capacity, malondialdehyde, advanced oxidation protein products, and 8-hydroxy-2-deoxyguanosine (8OHdG) concentrations were measured in both fluids. Women with EI/II showed higher FOX1 (8.48 +/- 1.72 vs. 7.69 +/- 1.71mol/g protein) and lower total antioxidant capacity (0.38 +/- 0.18 vs. 0.46 +/- 0.15mEq Trolox/L) concentrations in serum, and higher 8OHdG concentrations (24.21 +/- 8.56 vs. 17.22 +/- 5.6ng/ml) in follicular fluid compared with controls. These data implicate both systemic and follicular oxidative stress may in infertile women with EI/II undergoing controlled ovarian stimulation for ICSI. Furthermore, the elevated 8OHdG concentrations in follicular fluid of women with EI/II may be related to compromised oocyte quality. (AU) | |
| FAPESP's process: | 14/15866-6 - Annual Meeting of the American Society for Reproductive Medicine - ASRM2014 |
| Grantee: | Paula Andrea de Albuquerque Salles Navarro |
| Support Opportunities: | Research Grants - Meeting - Abroad |