Development and Evaluation of Lipid Nanoparticles Containing Natural Botanical Oil for Sun Protection: Characterization and in vitro and in vivo Human Skin Permeation and Toxicity

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Andreo-Filho, Newton ^[1] ; Kosiski Bim, Antonio Vinicius ^[1] ; Kaneko, Telma Mary ^[2] ; Kitice, Nidia Ayumi ^[1] ; Haridass, Isha N. ^{[3, 4]} ; Abd, Eman ^[3] ; Lopes, Patricia Santos ^[1] ; Thakur, Sachin S. ^[5] ; Parekh, Harendra S. ^[5] ; Roberts, Michael S. ^{[3, 6]} ; Grice, Jeffrey E. ^[3] ; Benson, Heather A. E. ^[4] ; Leite-Silva, Vania Rodrigues ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, UNIFESP Diadema, Dept Ciencias Farmaceut, Inst Ciencias Ambientais Quim & Farmaceut, BR-09913030 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharm, Sao Paulo - Brazil

^[3] Univ Queensland, Sch Med, Therapeut Res Ctr, Translat Res Inst, Brisbane, Qld - Australia

^[4] Curtin Univ, Sch Pharm, Curtin Hlth Innovat Res Inst, Perth, WA - Australia

^[5] Univ Queensland, Sch Pharm, PACE, Brisbane, Qld - Australia

^[6] Univ South Australia, Sch Pharm & Med Sci, Sansom Inst, Adelaide, SA - Australia

• Tipo de documento: Artigo Científico
• Fonte: SKIN PHARMACOLOGY AND PHYSIOLOGY; v. 31, n. 1, p. 1-9, 2018.
• Citações Web of Science: 6

Resumo

The use of sunscreen products is widely promoted by schools, government agencies, and health-related organizations to minimize sunburn and skin damage. In this study, we developed stable solid lipid nanoparticles (SLNs) containing the chemical UV filter octyl methoxycinnamate (OMC). In parallel, we produced similar stable SLNs in which 20% of the OMC content was replaced by the botanical urucum oil. When these SLNs were applied to the skin of human volunteers, no changes in fluorescence lifetimes or redox ratios of the endogenous skin fluorophores were seen, suggesting that the formulations did not induce toxic responses in the skin. Ex vivo (skin diffusion) tests showed no significant penetration. In vitro studies showed that when 20% of the OMC was replaced by urucum oil, there was no reduction in skin protection factor (SPF), suggesting that a decrease in the amount of chemical filter may be a viable alternative for an effective sunscreen, in combination with an antioxidant-rich vegetable oil, such as urucum. There is a strong trend towards increasing safety of sun protection products through reduction in the use of chemical UV filters. This work supports this approach by producing formulations with lower concentrations of OMC, while maintaining the SPF. Further investigations of SPF in vivo are needed to assess the suitability of these formulations for human use. (C) 2017 S. Karger AG, Basel (AU)

• Processo FAPESP: 14/16637-0 - Desenvolvimento de nanopartículas lipídicas seguras e eficazes, contendo filtro solar químico acrescido de óleos vegetais biossustenstáveis da flora brasileira
• Beneficiário: Vânia Rodrigues Leite e Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular