Convergent Evolution of Slick Coat in Cattle through Truncation Mutations in the Prolactin Receptor

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Porto-Neto, Laercio R. ^[1] ; Bickhart, Derek M. ^[2] ; Landaeta-Hernandez, Antonio J. ^[3] ; Utsunomiya, Yuri T. ^{[4, 5]} ; Pagan, Melvin ^[6] ; Jimenez, Esbal ^[6] ; Hansen, Peter J. ^[7] ; Dikmen, Serdal ^[8] ; Schroeder, Steven G. ^[9] ; Kim, Eui-Soo ^[10] ; Sun, Jiajie ^[11] ; Crespo, Edward ^[3] ; Amati, Norman ^[3] ; Cole, John B. ^[9] ; Null, Daniel J. ^[9] ; Garcia, Jose F. ^{[4, 5, 12]} ; Reverter, Antonio ^[1] ; Barendse, William ^[1] ; Sonstegard, Tad S. ^[10]

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^[1] CSIRO Agr & Food, St Lucia, Qld - Australia

^[2] ARS, US Dairy Forage Res Ctr, USDA, Madison, WI - USA

^[3] Univ Zulia, Fac Ciencias Vet, Unidad Invest Zootecn, Maracaibo - Venezuela

^[4] Sao Paulo State Univ, Sch Agr & Vet Sci, Dept Prevent Vet Med & Anim Reprod, Sao Paulo - Brazil

^[5] Collaborating Ctr Anim Genom & Bioinformat, Int Atom Energy Agcy, Aracatuba - Brazil

^[6] Univ Puerto Rico, Dept Anim Sci, Mayaguez, PR - USA

^[7] Univ Florida, Dept Anim Sci, Gainesville, FL 32611 - USA

^[8] Uludag Univ, Dept Anim Sci, Fac Vet Med, Bursa - Turkey

^[9] ARS, Anim Genom & Improvement Lab, USDA, Beltsville, MD - USA

^[10] Recombinet Inc, St Paul, MN 55104 - USA

^[11] South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong - Peoples R China

^[12] Sao Paulo State Univ, Sch Vet Med, Dept Support Prod & Anim Hlth, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN GENETICS; v. 9, FEB 23 2018.
• Citações Web of Science: 8

Resumo

Evolutionary adaptations are occasionally convergent solutions to the same problem. A mutation contributing to a heat tolerance adaptation in Senepol cattle, a New World breed of mostly European descent, results in the distinct phenotype known as slick, where an animal has shorter hair and lower follicle density across its coat than wild type animals. The causal variant, located in the 11th exon of prolactin receptor, produces a frameshift that results in a truncated protein. However, this mutation does not explain all cases of slick coats found in criollo breeds. Here, we obtained genome sequences from slick cattle of a geographically distinct criollo breed, namely Limonero, whose ancestors were originally brought to the Americas by the Spanish. These data were used to identify new causal alleles in the 11th exon of the prolactin receptor, two of which also encode shortened proteins that remove a highly conserved tyrosine residue. These new mutations explained almost 90% of investigated cases of animals that had slick coats, but which also did not carry the Senepol slick allele. These results demonstrate convergent evolution at the molecular level in a trait important to the adaptation of an animal to its environment. (AU)

• Processo FAPESP: 14/01095-8 - Utilização de sequenciamento de nova geração para o mapeamento fino de regiões cromossômicas que afetam o perímetro escrotal de touros Nelore
• Beneficiário: Yuri Tani Utsunomiya
• Modalidade de apoio: Bolsas no Brasil - Doutorado