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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Qualitative and Quantitative Analysis of Ethanolic Extract and Phenolic Fraction of Jatropha aethiopica (Euphorbiaceae) Leaves and Their Hypoglycemic Potential

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Autor(es):
Gamiotea-Turro, Daylin [1, 2] ; Camaforte, Nathalia A. P. [3] ; Valerino-Diaz, Alexander B. [2] ; Ortiz Nunez, Yarelis [1] ; Rinaldo, Daniel [4] ; Dokkedal, Anne L. [3] ; Bosqueiro, Jose R. [3] ; dos Santos, Lourdes Campaner [2]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Inst Fundamental Res Trop Agr Alejandro de Humbol, Calles 1&2, 17200, Havana 17200 - Cuba
[2] UNESP Sao Paulo State Univ, Chem Inst Araraquara, Rua Prof Francisco Degni, 55 Bairro Quitandinha, BR-14800060 Araraquara, SP - Brazil
[3] UNESP Sao Paulo State Univ, Dept Biol Sci, Fac Sci Bauru, Bairro Nucleo Habitac Presidente Geisel, Av Eng Luiz Edmundo C Coube 14-01, BR-17033360 Bauru, SP - Brazil
[4] UNESP Sao Paulo State Univ, Dept Chem Bauru, Bairro Nucleo Habitac Presidente Geisel, Av Eng Luiz Edmundo C Coube 14-01, BR-17033360 Bauru, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Journal of Agricultural and Food Chemistry; v. 66, n. 6, p. 1419-1427, FEB 14 2018.
Citações Web of Science: 2
Resumo

Although Jatropha aethiopica, popularly known in Cuba as ``mata diabetes{''}, is used in salads and as a dietary supplement, its chemical composition and antidiabetic properties yet remains unclear. In this work, we evaluate the qualitative and quantitative composition of ethanolic extract (EE) and phenolic fraction (PF) of Jatropha aethiopica leaves and their hypoglycemic and hypolipidemic activity. Chemical fractionation of the ethanolic extract yielded nine compounds, which included protocatechuic acid (1), chlorogenic acid (2), caffeic acid (3), quercetin 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-{[}alpha-L-rhamnopyranolsyl-(1 -> 6)]beta-D-galactopyranoside (4), a new kaempferol 3-0-alpha-L-rhamnopyranosyl-(1 -> 4)-{[}alpha-L-rhamnopyranolsyl-(1 -> 6)]-beta-D-galactopyranoside (5), kaempferol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-{[}alpha-L-rhamnopyranolsyl-(1 -> 6)]beta-n-glucopyranoside (6), rutin (7), kaempferol 3-O-alpha-L-rhamnopyranosyl-(1 -> 6)beta-D-glucopyranoside (8), and quercetin (9). The compounds (1, 4-7) were quantified by high-performance liquid chromatography photodiode array detection (HPLC-PDA) in both the ethanolic extract (62.65 +/- 0.15 mg/g) and phenolic fraction (61.72 +/- 0.23 mg/g). The results obtained show that both ethanolic extract and phenolic fraction contributed toward the improvement of glucose tolerance, which in turn led to a decline in the glucose levels. Remarkably, the ethanolic extract presented a relatively higher promising effect compared to metformin. (AU)

Processo FAPESP: 15/04899-3 - Estudo químico dos extratos produzidos por fungos endofíticos associados às partes aéreas de espécies de Eriocaulaceae e sua atividade antimicrobiana
Beneficiário:Lourdes Campaner dos Santos
Modalidade de apoio: Auxílio à Pesquisa - Regular