Genotype-guided warfarin therapy: current status

Autor(es)

Tavares, Leticia C. ^[1] ; Marcatto, Leiliane R. ^[1] ; Santos, Paulo C. J. L. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med FMUSP, Heart Inst InCor, Lab Genet & Mol Cardiol, BR-05403900 Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Pharmacol, BR-04044020 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PHARMACOGENOMICS; v. 19, n. 7, p. 667-685, MAY 2018.
• Citações Web of Science: 5

Resumo

Warfarin pharmacogenomics has been an extensively studied field in the last decades as it is focused on personalized therapy to overcome the wide interpatient warfarin response variability and decrease the risk of side effects. In this expert review, besides briefly summarizing the current knowledge about warfarin pharmacogenetics, we also present an overview of recent studies that aimed to assess the efficacy, safety and economic issues related to genotype-based dosing algorithms used to guide warfarin therapy, including randomized and controlled clinical trials, meta-analyses and cost-effectiveness studies. To date, the findings still present disparities, mostly because of standard limitations. Thus, further studies should be encouraged to try to demonstrate the benefits of the application of warfarin pharmacogenomic dosing algorithms in clinical practice. (AU)

• Processo FAPESP: 16/23454-5 - Avaliação de algoritmo estimador de dose de varfarina em pacientes sem dose estável
• Beneficiário: Leiliane Rodrigues Marcatto
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/09295-3 - Avaliação farmacogenética para fármacos do sistema cardiovascular com foco na implementação
• Beneficiário: Paulo Caleb Júnior de Lima Santos
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/22507-8 - Avaliação do impacto da inclusão de polimorfismos nos genes ABCB1 e CYP4F2 em algoritmo farmacogenético para dosagem personalizada do anticoagulante varfarina
• Beneficiário: Letícia Camargo Tavares
• Modalidade de apoio: Bolsas no Brasil - Mestrado