Leukocytoclastic vasculitis complicating cisplatin plus radiation treatment for laryngeal cancer: a case report

Autor(es)

Franca Quintanilha, Julia Coelho ^[1] ; Visacri, Marilia Berlofa ^[1] ; Amaral, Lais Sampaio ^[1] ; Passos Lima, Carmen Silvia ^[1] ; Cintra, Maria Leticia ^[1] ; Moriel, Patricia ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Sch Med Sci FCM, 126 Tessalia Vieira Camargo St, BR-13083887 Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Fac Pharmaceut Sci FCF, 200 Candido Portinari St, BR-13083871 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BMC CANCER; v. 17, DEC 6 2017.
• Citações Web of Science: 0

Resumo

Background: Leukocytoclastic vasculitis is typically mediated by deposition of immune complexes and is related to many causes, including medication. To the best of our knowledge, leukocytoclastic vasculitis related to cisplatin has not yet been described in the scientific literature. Case presentation: We report a rare case of leukocytoclastic vasculitis after the first cycle of high-dose cisplatin chemotherapy in a patient with larynx carcinoma. A 48-year-old Caucasian man with larynx carcinoma received a high-dose of cisplatin monochemotherapy (100 mg/m(2) every 21 days), along with 70 Gy of radiotherapy divided into 35 sessions, as a therapeutic schedule. Twelve days after the first chemotherapy administration and after 8 sessions of radiotherapy (total of 16 Gy), the patient presented with acute onset of palpable purpura in the lower limbs. The patient was hospitalized for 10 days, and during this period, he underwent several examinations to rule out infectious, autoimmune, and neoplastic disorders. A skin biopsy showed leukocytoclastic vasculitis with a positive pattern for IgM and C3, as detected through direct immunofluorescence. Twenty-five days after cisplatin administration, the chemotherapy regimen was changed to carboplatin AUC 5, and the episodes of purpura ceased, reinforcing the hypothesis of an adverse reaction to cisplatin. Conclusions: Cisplatin can induce leukocytoclastic vasculitis and clinicians should be aware of this potential effect for better case management and diagnosis. (AU)

• Processo FAPESP: 14/04744-7 - Avaliação do uso da N-acetilcisteína na atenuação de toxicidades causadas por estresse oxidativo em pacientes com câncer de cabeça e pescoço em tratamento com cisplatina
• Beneficiário: Marília Berlofa Visacri
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/18294-3 - Avaliação do uso da N-acetilcisteína na atenuação de toxicidades causadas por estresse oxidativo em pacientes com câncer de cabeça e pescoço em tratamento com cisplatina
• Beneficiário: Patricia Moriel
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/01793-0 - Estudo das reações adversas, qualidade de vida e estresse oxidativo celular em pacientes com câncer de cabeça e pescoço em tratamento com cisplatina e radioterapia
• Beneficiário: Júlia Coelho França Quintanilha
• Modalidade de apoio: Bolsas no Brasil - Mestrado