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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Bioavailability of di-peptide DL-methionyl-DL-methionine in comparison to DL-methionine in weaned and growing pigs

Texto completo
Autor(es):
Santos, L. S. [1] ; Htoo, J. K. [2] ; Fracaroli, C. [1] ; Silva, W. C. [1] ; Gobi, J. P. [1] ; Veira, A. M. [1] ; Barbosa, N. A. A. [3] ; Hauschild, L. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Sch Agr & Vet Sci, Anim Sci Dept, BR-14883108 Jaboticabal - Brazil
[2] Evon Nutr & Care GmbH, D-63457 Hanau - Germany
[3] Evon Degussa Brasil Ltda, BR-07222000 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: ANIMAL FEED SCIENCE AND TECHNOLOGY; v. 241, p. 94-101, JUL 2018.
Citações Web of Science: 2
Resumo

The relative bioavailability (RBV) of a dipeptide nt-methionyl-DL-methionine (DL-Met-Met) was compared with ot-methionine (DL-Met) in growing pigs (experiment 1; N-balance study) and in weaned pigs (experiment 2; performance study). In experiment 1, 42 barrows with an initial body weight (BW) of 21.0 +/- 1.37 kg were assigned to 7 dietary treatments with 6 replicate/pigs per treatment in a nitrogen (N) balance study to evaluate the RBV of DL-Met-Met to DL-Met. A basal diet (BD) was formulated to be adequate for all amino acids with the exception of Met + Cys which was 68% of the requirement {[}4.7 g/kg standardized ileal digestible (SID) Met + Cys; 11.5 g/kg SID Lys] for 20-25 kg pigs. Three graded levels of DL-Met (0.3, 0.6 and 0.9 g/kg) and DL-Met-Met (0.306, 0.612 and 0.919 g/kg) were supplemented to the BD to create diets 2-7. In experiment 2, a total of 189 weaned pigs (initial BW of 10.2 +/- 0.98 kg) were assigned to 7 dietary treatments with 9 replicates/pens of 3 pigs per treatment. The dietary treatments consisted of a Met-deficient BD (5.3 g/kg SID Met + Cys; 13.0 g/kg SID Lys) and the same 3 graded levels of DL-Met and DL-Met-Met as in Exp. 1. In experiment 1, supplementation with DL-Met or DL Met-Met linearly decreased (P <= 0.01; linear) urinary N excretion and increased (P <= 0.02; linear) N retained (g/day), N retention (% of intake and % of absorbed). However, there was no effect of Met sources on all N balance parameters. Based on the slope-ratio regression the RBV for DL-Met-Met compared to DL-Met was estimated 111% {[}95% confidence interval (CI): 63-158%] for N retained (g/d), 109% (95% CI: 57-160%) for N retention (% of intake) and 98% (95% CI: 43-154%) for N retention (% of absorbed) on an equi-molar basis. In experiment 2, the overall average daily gain (ADG) and gain:feed ratio (G:F) increased linearly (P < 0.01) by supplementation with DL-Met or DL-Met-Met. The average daily feed intake increased by supplementation with DL-Met (P = 0.02) and DL-Met-Met (P = 0.09). For ADG, the RBV for DL-Met-Met was estimated 104% (95% CI: 66-141%) on an equi-molar basis by the slope-ratio. Based on G:F, the RBV for DL-Met-Met was estimated 117% (95% CI: 61-174%) on an equi-molar basis. The results of both experiments indicate that the bioavailability DL-Met-Met is not different and at least equally bioavailable as DL-Met as a Met source for pigs. (AU)

Processo FAPESP: 15/05241-1 - Sistema de alimentação de precisão como alternativa sustentável para produção de suínos em países de clima tropical
Beneficiário:Luan Sousa dos Santos
Linha de fomento: Bolsas no Brasil - Doutorado