| Texto completo | |
| Autor(es): |
Sales, Amanda J.
[1]
;
Crestani, Carlos C.
[2]
;
Guimaraes, Francisco S.
[1, 3]
;
Joca, Samia R. L.
[3, 4, 5]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Ribeirao Preto, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci Araraquara, Lab Pharmacol, Araraquara, SP - Brazil
[3] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Ribeirao Preto, SP - Brazil
[5] Aarhus Univ, Translat Neuropsychiat Unit, Dept Clin Med, Aarhus - Denmark
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 86, p. 255-261, AUG 30 2018. |
| Citações Web of Science: | 11 |
| Resumo | |
Cannabidiol (CBD) is a compound of Cannabis sativa with relevant therapeutic potential in several neuropsychiatric disorders including depression. CBD treatment has shown significant antidepressant-like effects in different rodent preclinical models. However, the mechanisms involved in CBD-induced antidepressant effects are still poorly understood. Therefore, this work aimed at investigating the participation of serotonin (5 HT) and/or noradrenaline (NA) in CBD-induced antidepressant-like effects in the forced swimming test (FST) by: 1) testing if CBD co-administration with serotonergic (fluoxetine, FLX) or noradrenergic (desipramine, DES) antidepressants would have synergistic effects; and 2) investigating if 5 HT or NA depletion would impair CBD-induced behavioral effects. Results showed that CBD (10 mg/kg), FLX (10 mg/kg) and DES (5 mg/kg) induced antidepressant-like effects in mice submitted to FST. Ineffective doses of CBD (7 mg/kg), when co-administered with ineffective doses of FLX (5 mg/kg) or DES (2.5 mg/kg) resulted in significant antidepressant-like effects, thus implicating synergistic and/or additive mechanisms. Pretreatment with PCPA (an inhibitor of serotonin synthesis: 150 mg/kg, i.p., once per day for 4 days), but not DSP 4 (a noradrenergic neurotoxin: 1 mu g/mu l, i.c.v., 24 h before the test), reduced monoamine levels in the brain. However, only PCPA treatment abolished CBD-induced behavioral effects in FST, indicating the participation of serotonergic mechanisms. None of the treatments induced locomotor effects. Our results suggest that the antidepressant-like effect induced by CBD in the FST is dependent on serotonin levels in the central nervous system (CNS). (AU) | |
| Processo FAPESP: | 15/01955-0 - Efeito do tratamento com inibidores de DNMTs e com antidepressivos sobre a metilação do DNA em genes candidatos envolvidos com a neurobiologia da depressão |
| Beneficiário: | Amanda Juliana Sales |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |