Nanofibrous scaffolds for biomedical applications

Autor(es)

Stocco, Thiago D. ^{[1, 2]} ; Bassous, Nicole J. ^[3] ; Zhao, Siqi ^[3] ; Granato, Alessandro E. C. ^[4] ; Webster, Thomas J. ^[3] ; Lobo, Anderson O. ^{[5, 6, 7]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Ciencias Med, Sao Paulo - Brazil

^[2] Univ Santo Amaro, Fac Fisioterapia, Sao Paulo - Brazil

^[3] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 - USA

^[4] Univ Fed Sao Paulo, Dept Bioquim, Sao Paulo - Brazil

^[5] MIT, Dept Chem, Cambridge, MA 02139 - USA

^[6] Univ Brasil, Inst Ciencia & Tecnol, Sao Paulo - Brazil

^[7] Univ Fed Piaui, Programa Posgrad Ciencia & Engn Mat, Teresina, PI - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NANOSCALE; v. 10, n. 26, p. 12228-12255, JUL 14 2018.
• Citações Web of Science: 12

Resumo

Tissue engineering is an emergent and very interesting research field, providing potential solutions for a myriad of challenges in healthcare. Fibrous scaffolds specifically have shown promise as an effective tissue engineering method, as their high length-to-width ratio mimics that of extracellular matrix components, which in turn guides tissue formation, promotes cellular adhesion and improves mechanical properties. In this review paper, we discuss in detail both the importance of fibrous scaffolds for the promotion of tissue growth and the different methods to produce fibrous biomaterials to possess favorable and unique characteristics. Here, we focus on the pressing need to develop biomimetic structures that promote an ideal environment to encourage tissue formation. In addition, we discuss different biomedical applications in which fibrous scaffolds can be useful, identifying their importance, relevant aspects, and remaining significant challenges. In conclusion, we provide comments on the future direction of fibrous scaffolds and the best way to produce them, proposed in light of recent technological advances and the newest and most promising fabrication techniques. (AU)

• Processo FAPESP: 15/09697-0 - Eletrofiação de novos nanobiomateriais funcionais à base de peptídeos e polímeros bottlebrush para engenharia tecidual
• Beneficiário: Anderson de Oliveira Lobo
• Modalidade de apoio: Bolsas no Exterior - Pesquisa