An Overview of Biotransformation and Toxicity of Diterpenes

Autor(es)

de Sousa, Ingrid P. ^[1] ; Sousa Teixeira, Maria V. ^[1] ; Jacometti Cardoso Furtado, Niege A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, Av Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Molecules; v. 23, n. 6 JUN 2018.
• Citações Web of Science: 2

Resumo

Diterpenes have been identified as active compounds in several medicinal plants showing remarkable biological activities, and some isolated diterpenes are produced at commercial scale to be used as medicines, food additives, in the synthesis of fragrances, or in agriculture. There is great interest in developing methods to obtain derivatives of these compounds, and biotransformation processes are interesting tools for the structural modification of natural products with complex chemical structures. Biotransformation processes also have a crucial role in drug development and/or optimization. The understanding of the metabolic pathways for both phase I and II biotransformation of new drug candidates is mandatory for toxicity and efficacy evaluation and part of preclinical studies. This review presents an overview of biotransformation processes of diterpenes carried out by microorganisms, plant cell cultures, animal and human liver microsomes, and rats, chickens, and swine in vivo and highlights the main enzymatic reactions involved in these processes and the role of diterpenes that may be effectively exploited by other fields. (AU)

• Processo FAPESP: 16/25201-7 - Estudos de bioacessibilidade, transporte intestinal e biotransformação in vitro dos ácidos ent-hardwickiico e ent-poliáltico das oleorresinas de Copaifera pubiflora e Copaifera duckei
• Beneficiário: Niege Araçari Jacometti Cardoso Furtado
• Modalidade de apoio: Auxílio à Pesquisa - Regular