The AGTR2 rs11091046 (A > C) polymorphism and power athletic status in top-level Brazilian athletes

Autor(es)

Limongi Franca Guilherme, Joao Paulo ^[1] ; Silva, Mariana Sussi ^[1] ; Bertuzzi, Romulo ^[2] ; Lancha Junior, Antonio Herbert ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Appl Nutr & Metab, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport, Endurance Performance Res Grp, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF SPORTS SCIENCES; v. 36, n. 20, p. 2327-2332, 2018.
• Citações Web of Science: 6

Resumo

The main purpose of this study was to investigate if the rs11091046 (A>C) polymorphism in AGTR2 gene is associated with athletic status in top-level athletes from Brazil. Since the AGTR2 gene is located on the X chromosome, the case-control association study was done separately for women and men. The female cohort was composed of 205 athletes and 241 non-athletes, and the male cohort was composed of 419 athletes and 490 non-athletes. We did not identify an association between the C-allele and the endurance phenotype. However, power athletes had a higher frequency of the A-allele. In women, A/A genotype was overrepresented in international-level power group compared with non-athletes or international-level endurance athletes (23.2% vs. 16.6% or 8.8%, respectively; p<0.05). In men, the A-allele frequency observed in power athletes or international-level power athletes was statistically different from that observed in non-athletes (51.6% or 57.8% vs. 40.4%; p<0.009). Furthermore, men sprinters with the A-allele showed significantly faster personal best times for the 100m than those with the C-allele (10.56 +/- 0.32s vs. 10.93 +/- 0.49s; p<0.02). In conclusion, it was found that the AGTR2 A-allele is a candidate genetic marker for top-level power athletes. (AU)

• Processo FAPESP: 12/22516-6 - Perfil poligênico de atletas brasileiros: distribuição de polimorfismos associados ao desempenho físico
• Beneficiário: João Paulo Limongi França Guilherme
• Modalidade de apoio: Bolsas no Brasil - Doutorado