Chemical interaction of endophytic fungi and actinobacteria from Lychnophora ericoides in co-cultures

Autor(es)

Chagas, Fernanda O. ^{[1, 2]} ; Pupo, Monica T. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, FCFRP, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Rio de Janeiro, Inst Pesquisas Prod Nat Walter Mors IPPN, Av Carlos Chagas Filho 373, Cidade Univ, BR-21941902 Rio de Janeiro, RJ - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MICROBIOLOGICAL RESEARCH; v. 212, p. 10-16, 2018.
• Citações Web of Science: 1

Resumo

Microorganisms interact chemically in natural environments; however, the compounds and mechanisms involved in this phenomenon are still poorly understood. Using the cocultivation approach, changes in metabolic profiles due to interactions between endophytic fungal and actinobacterial strains isolated from the plant Lychnophora ericoides (Asteraceae) were assessed. The production of the cytotoxic compound cytochalasin H by the fungus Phomopsis sp. FLe6 was remarkably inhibited in solid and liquid co-cultures with the actinobacteria Streptomyces albospinus RLe7. This was a consequence of the fungal growth inhibition caused by antifungal compounds produced by S. albospinus RLe7, including amphotericin B. Cytochalasin H is not toxic to S. albospinus RLe7, suggesting that this microorganism does not require a defense mechanism to prevent the potentially harmful effects of such fungal compound. By exhibiting various competitive phenotypes, these microbes can control each other's growth when sharing an environment. (AU)

• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 08/09540-0 - Novas estratégias na pesquisa em antibióticos naturais: microrganismos simbiontes como fontes de substâncias e ensaio in vivo baseado no modelo de infecção em Caenorhabditis elegans
• Beneficiário: Mônica Tallarico Pupo
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/17695-6 - Novas estratégias para acessar produtos naturais microbianos: culturas mistas de endofíticos, modulação química e epigenética de vias biossintéticas
• Beneficiário: Fernanda Oliveira das Chagas
• Linha de fomento: Bolsas no Brasil - Doutorado