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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical interaction of endophytic fungi and actinobacteria from Lychnophora ericoides in co-cultures

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Author(s):
Chagas, Fernanda O. [1, 2] ; Pupo, Monica T. [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, FCFRP, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Fed Rio de Janeiro, Inst Pesquisas Prod Nat Walter Mors IPPN, Av Carlos Chagas Filho 373, Cidade Univ, BR-21941902 Rio de Janeiro, RJ - Brazil
Total Affiliations: 2
Document type: Journal article
Source: MICROBIOLOGICAL RESEARCH; v. 212, p. 10-16, 2018.
Web of Science Citations: 1
Abstract

Microorganisms interact chemically in natural environments; however, the compounds and mechanisms involved in this phenomenon are still poorly understood. Using the cocultivation approach, changes in metabolic profiles due to interactions between endophytic fungal and actinobacterial strains isolated from the plant Lychnophora ericoides (Asteraceae) were assessed. The production of the cytotoxic compound cytochalasin H by the fungus Phomopsis sp. FLe6 was remarkably inhibited in solid and liquid co-cultures with the actinobacteria Streptomyces albospinus RLe7. This was a consequence of the fungal growth inhibition caused by antifungal compounds produced by S. albospinus RLe7, including amphotericin B. Cytochalasin H is not toxic to S. albospinus RLe7, suggesting that this microorganism does not require a defense mechanism to prevent the potentially harmful effects of such fungal compound. By exhibiting various competitive phenotypes, these microbes can control each other's growth when sharing an environment. (AU)

FAPESP's process: 09/17695-6 - New strategies to access microbial natural products: mixed cultures of endophytes, chemical and epigenetic remodeling of biosynthetic pathways
Grantee:Fernanda Oliveira das Chagas
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 08/09540-0 - New strategies in the search of natural antibiotics: symbiotic microorganisms as sources of compounds and in vivo assay based on Caenorhabditis elegans infection model
Grantee:Mônica Tallarico Pupo
Support type: Regular Research Grants
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC