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Metabolic syndrome impact on cardiac autonomic modulation and exercise capacity in obese adults

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Carvalho, Livia P. [1] ; Di Thommazo-Luporini, Luciana [1] ; Mendes, Renata G. [1] ; Cabiddu, Ramona [1] ; Ricci, Paula A. [1] ; Basso-Vanelli, Renata P. [1] ; Oliveira-Junior, Manoel C. [2] ; Vieira, Rodolfo P. [3] ; Bonjorno-Junior, Jose C. [4] ; Oliveira, Claudio R. [4] ; Luporini, Rafael L. [4] ; Borghi-Silva, Audrey [1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Phys Therapy, Sao Carlos, SP - Brazil
[2] Nove Julho Univ, Brazilian Inst Teaching & Res Pulm & Exercise Imm, Lab Pulm & Exercise Immunol LABPEI, Sao Paulo, SP - Brazil
[3] Univ Brasil, Sch Med Sci Sao Jose Dos Campos Humanitas, Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos, SP - Brazil
[4] Univ Fed Sao Carlos, Dept Med, Sao Carlos, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Citações Web of Science: 4

Obesity is often associated with increased risk of cardiometabolic morbidities and mortality. However, evidence shows that some obese individuals are more likely to develop such risk factors early in life, including those with Metabolic Syndrome (MetS). Whether the presence of MetS in obese people impairs cardiac autonomic modulation (CAM) remains to be investigated. Methods: Cross-sectional study. Sixty-six subjects were classified as normal-weight (NW, n = 24) or obese (BMI >= 30 kg.m(-2)): metabolically healthy (MHO, n = 19) vs unhealthy (MUHO, n = 23: NCEP/ATPIII-MetS criteria). Body composition (bioimpedance), metabolic (glucose-insulin/lipid) and inflammatory profiles were determined. Linear and nonlinear heart rate variability (HRV) indices were computed at rest and during the submaximal six-minute step test (6MST). Blood pressure (BP) and metabolic and ventilatory variables were assessed (oxygen uptake, VO2; carbon dioxide production, VCO2; minute ventilation, V-E) during the 6MST and the maximal cardiopulmonary exercise testing (CPX). Results: All groups reached the same 6MST intensity (VO2 similar to 80% and HR similar to 87% of CPX peak values). Both obese groups, independently of MetS, presented higher BP and lower maximal VO2 than NW. However, HRV differed between groups according to MetS at rest and during exercise: MUHO had lower meanRRi and SD1 than NW and lower RMSSD and pNN50 than MHO at rest; during exercise, the lowest SDNN, TINN, SD1 and Shannon entropy were observed for MUHO. Significant correlations were found between MetS, insulin resistance and HRV indices; and between insulin resistance and aerobic capacity (VO2peak). Conclusion: Obesity per se impairs aerobic-hemodynamic responses to exercise. However, MetS in obese young adults negatively impacts overall HRV, parasympathetic activity and HRV complexity. (AU)

Processo FAPESP: 15/04101-1 - Efeitos clínicos, funcionais e sistêmicos da estimulação elétrica neuromuscular corpórea no pós-operatório de cirurgia bariátrica.
Beneficiário:Audrey Borghi e Silva
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/15681-3 - Relacionamento entre estrutura e função muscular periférica, inflamação sistêmica e regulação autonômica em adultos obesos
Beneficiário:Lívia Pinheiro Carvalho
Linha de fomento: Bolsas no Brasil - Doutorado Direto