Metabolic syndrome impact on cardiac autonomic modulation and exercise capacity in obese adults

Author(s):Show less -

Carvalho, Livia P. ^[1] ; Di Thommazo-Luporini, Luciana ^[1] ; Mendes, Renata G. ^[1] ; Cabiddu, Ramona ^[1] ; Ricci, Paula A. ^[1] ; Basso-Vanelli, Renata P. ^[1] ; Oliveira-Junior, Manoel C. ^[2] ; Vieira, Rodolfo P. ^[3] ; Bonjorno-Junior, Jose C. ^[4] ; Oliveira, Claudio R. ^[4] ; Luporini, Rafael L. ^[4] ; Borghi-Silva, Audrey ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Phys Therapy, Sao Carlos, SP - Brazil

^[2] Nove Julho Univ, Brazilian Inst Teaching & Res Pulm & Exercise Imm, Lab Pulm & Exercise Immunol LABPEI, Sao Paulo, SP - Brazil

^[3] Univ Brasil, Sch Med Sci Sao Jose Dos Campos Humanitas, Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos, SP - Brazil

^[4] Univ Fed Sao Carlos, Dept Med, Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 213, p. 43-50, SEP 2018.
• Web of Science Citations: 4

Abstract

Obesity is often associated with increased risk of cardiometabolic morbidities and mortality. However, evidence shows that some obese individuals are more likely to develop such risk factors early in life, including those with Metabolic Syndrome (MetS). Whether the presence of MetS in obese people impairs cardiac autonomic modulation (CAM) remains to be investigated. Methods: Cross-sectional study. Sixty-six subjects were classified as normal-weight (NW, n = 24) or obese (BMI >= 30 kg.m(-2)): metabolically healthy (MHO, n = 19) vs unhealthy (MUHO, n = 23: NCEP/ATPIII-MetS criteria). Body composition (bioimpedance), metabolic (glucose-insulin/lipid) and inflammatory profiles were determined. Linear and nonlinear heart rate variability (HRV) indices were computed at rest and during the submaximal six-minute step test (6MST). Blood pressure (BP) and metabolic and ventilatory variables were assessed (oxygen uptake, VO2; carbon dioxide production, VCO2; minute ventilation, V-E) during the 6MST and the maximal cardiopulmonary exercise testing (CPX). Results: All groups reached the same 6MST intensity (VO2 similar to 80% and HR similar to 87% of CPX peak values). Both obese groups, independently of MetS, presented higher BP and lower maximal VO2 than NW. However, HRV differed between groups according to MetS at rest and during exercise: MUHO had lower meanRRi and SD1 than NW and lower RMSSD and pNN50 than MHO at rest; during exercise, the lowest SDNN, TINN, SD1 and Shannon entropy were observed for MUHO. Significant correlations were found between MetS, insulin resistance and HRV indices; and between insulin resistance and aerobic capacity (VO2peak). Conclusion: Obesity per se impairs aerobic-hemodynamic responses to exercise. However, MetS in obese young adults negatively impacts overall HRV, parasympathetic activity and HRV complexity. (AU)

• FAPESP's process: 13/15681-3 - Relationship between peripheral muscle structure and function, inflammation and autonomic regulation in exercise capacity in obese adults
• Grantee: Lívia Pinheiro Carvalho
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 15/04101-1 - Clinical, functional and systemic effects of whole-body electrical stimulation after bariatric surgery
• Grantee: Audrey Borghi Silva
• Support Opportunities: Regular Research Grants