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Clinical, functional and systemic effects of whole-body electrical stimulation after bariatric surgery

Abstract

Background: Obesity is a chronic multifactorial disease resulting from many interactions. The success of the pharmacological and non-pharmacological interventions (exercise and diet) are still contradictory in obese patients. Bariatric surgery often becomes a fast and effective intervention in cases of morbid obesity and/or obesity associated with comorbidities. The conventional gastric bypass surgery, associated with dietary restriction in the first weeks, limits the physical activity performance. In this context, whole-body neuromuscular electrical stimulation (WBS), which has been a recent strategy that stimulates simultaneously several and large muscle groups, has become a promising and innovative option to enhance weight loss, improve exercise capacity and peripheral muscle strength, and positively impact on systemic effects.Objectives: To evaluate the functional capacity, the strength parameters and muscular endurance, anti-inflammatory and proinflammatory circulating markers and the autonomic control of heart rate in candidates for bariatric surgery, before and after the surgical intervention, applying the WBS as a strategy to early rehabilitation.Hypothesis: it is speculated that WBS can enhance the performance, muscular strength, and endurance parameters, as well as reduce inflammatory markers, and improve autonomic control of heart rate in these patients compared with controls (sham).Study Design: A randomized, duble blind placebo controlled clinical trial.Methods: Thirty-two obese subjects (BMI > 35 Kg/m2) will be randomized into 2 groups (EENMC=16) and control group (Sham=16)). In the preoperative period, the volunteers will perform several assessments: pulmonary function, maximal and submaximal exercise capacity, blood inflammatory markers, strength and endurance of quadriceps, as well as the autonomic control of heart rate (HR) at rest and during submaximal exercises. In the second day after discharge, the subjects will be evaluated regarding the functional capacity by means of the 6MWT and 2MST, the body composition data and the HR. The patients will be treated by either WBS or sham-US for 30 sessions, five days per week, during 6-consecutive weeks. After this treatment period, all the preoperative assessments will be performed again.Relevance of the study: Considering the reasoning in the academic and clinical role of the neuromuscular electrical stimulation on skeletal muscle conditioning and its value as an aid strategy in exercise performance and muscle strength, this proposal is important since it will expand the use of this new therapeutic strategy (WBS), assessing under controlled conditions, the effects of it in postoperative bariatric surgery patients. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RICCI, PAULA ANGELICA; ANDRE, LARISSA DELGADO; JURGENSEN, SORAIA PILON; DE OLIVEIRA, CLAUDIO RICARDO; ORTEGA, FERNANDO PINHEIRO; DI THOMMAZO-LUPORINI, LUCIANA; BORGHI-SILVA, AUDREY. Responses of different functional tests in candidates for bariatric surgery and the association with body composition, metabolic and lipid profile. SCIENTIFIC REPORTS, v. 11, n. 1, . (18/13332-5, 15/04101-1)
SILVA, ANDREA L. G.; GOULART, CASSIA L.; MANSOUR, KAMILA M. K.; BACK, GUILHERME D.; CABIDDU, RAMONA; TRIMER, RENATA; BORGHI-SILVA, AUDREY. Acute effects of expiratory positive pressure on autonomic cardiac modulation during spontaneous and stow deep breathing in COPD patients. Anais da Academia Brasileira de Ciências, v. 92, n. 2, . (13/23013-0, 15/04101-1)
GABRIELA CASSEMILIANO; PAULA ANGÉLICA RICCI; SORAIA PILON JÜRGENSEN; BIANCA CRISTINA DOMINGOS; AUDREY BORGHI-SILVA. Acute whole-body electromyostimulation associated with dynamic exercises did not alter cardiac autonomic modulation and oxygen uptake in obese and eutrophic men. Motriz: rev. educ. fis., v. 28, . (15/04101-1, 18/13332-5, 17/22895-0)
ANDRÉA L.G. DA SILVA; CÁSSIA L. GOULART; KAMILA M.K. MANSOUR; GUILHERME D. BACK; RAMONA CABIDDU; RENATA TRIMER; AUDREY BORGHI-SILVA. Acute effects of expiratory positive pressure on autonomic cardiac modulation during spontaneous and slow deep breathing in COPD patients. Anais da Academia Brasileira de Ciências, v. 92, n. 2, . (13/23013-0, 15/04101-1)
SIMOES, RODRIGO P.; MENDES, RENATA G.; CASTELLO-SIMOES, VIVIANE; CATAI, APARECIDA M.; ARENA, ROSS; BORGHI-SILVA, AUDREY. Use of Heart Rate Variability to Estimate Lactate Threshold in Coronary Artery Disease Patients during Resistance Exercise. JOURNAL OF SPORTS SCIENCE AND MEDICINE, v. 15, n. 4, p. 649-657, . (15/12763-4, 15/04101-1)
ANDRE, LARISSA DELGADO; BASSO-VANELLI, RENATA P.; DI THOMMAZO-LUPORINI, LUCIANA; RICCI, PAULA ANGELICA; CABIDDU, RAMONA; JURGENSEN, SORAIA PILON; DE OLIVEIRA, CLAUDIO RICARDO; ARENA, ROSS; BORGHI-SILVA, AUDREY. Functional and systemic effects of whole body electrical stimulation post bariatric surgery: study protocol for a randomized controlled trial. Trials, v. 19, . (15/04101-1)
RICCI, PAULA ANGELICA; DI THOMMAZO-LUPORINI, LUCIANA; JURGENSEN, SORAIA PILON; ANDRE, LARISSA DELGADO; HADDAD, GUILHERME FOCCHI; ARENA, ROSS; BORGHI-SILVA, AUDREY. Effects of Whole-Body Electromyostimulation Associated with Dynamic Exercise on Functional Capacity and Heart Rate Variability After Bariatric Surgery: a Randomized, Double-Blind, and Sham-Controlled Trial. OBESITY SURGERY, v. 30, n. 10, . (18/13332-5, 15/04101-1)
ANDRE, LARISSA DELGADO; BASSO-VANELLI, RENATA PEDROLONGO; RICCI, PAULA ANGELICA; DI THOMMAZO-LUPORINI, LUCIANA; DE OLIVEIRA, CLAUDIO RICARDO; HADDAD, GUILHERME FOCCHI; HADDAD, JOSE MICHEL; PARIZOTTO, NIVALDO ANTONIO; DE VIEIRA, RODOLFO; ARENA, ROSS; et al. hole-body electrical stimulation as a strategy to improve functional capacity and preserver lean mass after bariatric surgery: a randomized triple-blind controlled tria. International Journal of Obesity, v. 45, n. 7, p. 1476-1487, . (15/04101-1)
CARVALHO, LIVIA P.; DI THOMMAZO-LUPORINI, LUCIANA; MENDES, RENATA G.; CABIDDU, RAMONA; RICCI, PAULA A.; BASSO-VANELLI, RENATA P.; OLIVEIRA-JUNIOR, MANOEL C.; VIEIRA, RODOLFO P.; BONJORNO-JUNIOR, JOSE C.; OLIVEIRA, CLAUDIO R.; et al. Metabolic syndrome impact on cardiac autonomic modulation and exercise capacity in obese adults. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 213, p. 43-50, . (15/04101-1, 13/15681-3)
CARVALHO, LIVIA PINHEIRO; BASSO-VANELLI, RENATA PEDROLONGO; DI THOMMAZO-LUPORINI, LUCIANA; MENDES, RENATA GONCALVES; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; VIEIRA, RODOLFO DE PAULA; BONJORNO-JUNIOR, JOSE CARLOS; OLIVEIRA, CLAUDIO RICARDO; LUPORINI, RAFAEL; BORGHI-SILVA, AUDREY. Myostatin and adipokines: The role of the metabolically unhealthy obese phenotype in muscle function and aerobic capacity in young adults. CYTOKINE, v. 107, p. 118-124, . (15/04101-1, 13/15681-3)

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