Nutritional assessment in cirrhotic patients with hepatic encephalopathy

Autor(es)

Romeiro, Fernando Gomes ^[1] ; Augusti, Lais ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Dept Internal Med, Gastroenterol Div, Botucatu Med Sch, Dist Rubino Jr S-N, BR-18608917 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: WORLD JOURNAL OF HEPATOLOGY; v. 7, n. 30, p. 2940-2954, DEC 28 2015.
• Citações Web of Science: 10

Resumo

Hepatic encephalopathy (HE) is one of the worst complications of liver disease and can be greatly influenced by nutritional status. Ammonia metabolism, inflammation and muscle wasting are relevant processes in HE pathophysiology. Malnutrition worsens the prognosis in HE, requiring early assessment of nutritional status of these patients. Body composition changes induced by liver disease and limitations superimposed by HE hamper the proper accomplishment of exams in this population, but evidence is growing that assessment of muscle mass and muscle function is mandatory due to the role of skeletal muscles in ammonia metabolism. In this review, we present the pathophysiological aspects involved in HE to support further discussion about advantages and drawbacks of some methods for evaluating the nutritional status of cirrhotic patients with HE, focusing on body composition. (AU)

• Processo FAPESP: 13/15121-8 - Ensaio clínico prospectivo, randomizado, duplo-cego e controlado sobre os efeitos da leucina versus isoleucina no tratamento da encefalopatia hepática de acordo com o estado nutricional de portadores de cirrose
• Beneficiário: Lais Augusti
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/11761-2 - Estudo clínico randomizado, duplo-cego e controlado sobre a ação de aminoácidos de cadeia ramificada sobre o pH sanguíneo e o fluxo cerebral de portadores de cirrose com encefalopatia hepática
• Beneficiário: Fernando Gomes Romeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular