Nutritional assessment in cirrhotic patients with hepatic encephalopathy

Author(s)

Romeiro, Fernando Gomes ^[1] ; Augusti, Lais ^[1]

Affiliation

^[1] UNESP Univ Estadual Paulista, Dept Internal Med, Gastroenterol Div, Botucatu Med Sch, Dist Rubino Jr S-N, BR-18608917 Botucatu, SP - Brazil

• Document type: Journal article
• Source: WORLD JOURNAL OF HEPATOLOGY; v. 7, n. 30, p. 2940-2954, DEC 28 2015.
• Web of Science Citations: 10

Abstract

Hepatic encephalopathy (HE) is one of the worst complications of liver disease and can be greatly influenced by nutritional status. Ammonia metabolism, inflammation and muscle wasting are relevant processes in HE pathophysiology. Malnutrition worsens the prognosis in HE, requiring early assessment of nutritional status of these patients. Body composition changes induced by liver disease and limitations superimposed by HE hamper the proper accomplishment of exams in this population, but evidence is growing that assessment of muscle mass and muscle function is mandatory due to the role of skeletal muscles in ammonia metabolism. In this review, we present the pathophysiological aspects involved in HE to support further discussion about advantages and drawbacks of some methods for evaluating the nutritional status of cirrhotic patients with HE, focusing on body composition. (AU)

• FAPESP's process: 13/15121-8 - The effects of leucine versus isoleucine in the treatment of hepatic encephalopathy, according to the nutritional status of cirrhotic patients: a randomized, double blind controlled trial
• Grantee: Lais Augusti
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 13/11761-2 - Effect of isolated branched chain amino acids in the serum pH and cerebral blood flow of cirrhotic patients: a randomized, double blind controlled trial
• Grantee: Fernando Gomes Romeiro
• Support Opportunities: Regular Research Grants