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Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model in cirrhotic patients

Grant number: 11/13243-3
Support type:Regular Research Grants
Duration: May 01, 2012 - April 30, 2015
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Dan Linetzky Waitzberg
Grantee:Dan Linetzky Waitzberg
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Malnutrition due to liver disease is common, however, its diagnosis is difficult. The parameters used for nutritional assessment in clinical practice have limited use in this patient population. From this perspective, this study proposes to develop predictive equations for body composition for bioelectrical impedance (BIA) in cirrhotic patients. Besides being a fast and risk free method, the BIA offers the additional advantage of low cost compared to other methods that evaluate body composition (BC). It will be selected patients with liver cirrhosis (n = 50) from the Liver Transplant Clinic of the Medicine School Hospital from the University of São Paulo, and healthy volunteers (n = 50) for the control group. After signing an informed consent, the patient sample will be divided into three groups according to the criteria of Child-Pugh (A, B or C), and their BC will be estimated by bioelectrical impedance analysis and by a reference method (multicomponent model). The data obtained by both methods will be statistically treated to obtain specific BIA prediction equations for the evaluation of cirrhotic patients. This pioneering study is of great clinical importance because malnutrition is a relevant factor in the prognosis of liver disease and there is not efficient method in clinical practice to properly assess the body composition in this patient category. Such knowledge, in turn, can be used as a new tool for nutritional assistance in treating this disease. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BELARMINO, G.; SINGER, P.; GONZALEZ, M. C.; MACHADO, N. M.; CARDINELLI, C. S.; BARCELOS, S.; ANDRAUS, W.; D'ALBUQUERQUE, L. A. C.; DAMIANI, L.; COSTA, A. C.; PEREIRA, R. M. R.; HEYMSFIELD, S. B.; SALA, P.; TORRINHAS, R. S. M.; WAITZBERG, D. L. Prognostic value of energy expenditure and respiratory quotient measuring in patients with liver cirrhosis. Clinical Nutrition, v. 38, n. 4, p. 1899-1904, AUG 2019. Web of Science Citations: 0.
BELARMINO, GILIANE; GONZALEZ, MARIA CRISTINA; SALA, PRISCILA; TORRINHAS, RAQUEL SUSANA; ANDRAUS, WELLINGTON; CARNEIRO D'ALBUQUERQUE, LUIZ AUGUSTO; PEREIRA, ROSA MARIA R.; CAPARBO, VALERIA F.; FERRIOLI, EDUARDO; PFRIMER, KARINA; DAMIANI, LUCAS; HEYMSFIELD, STEVEN B.; WAITZBERG, DAN L. Diagnosing Sarcopenia in Male Patients With Cirrhosis by Dual-Energy X-Ray Absorptiometry Estimates of Appendicular Skeletal Muscle Mass. Journal of Parenteral and Enteral Nutrition, v. 42, n. 1, p. 24-36, JAN 2018. Web of Science Citations: 8.
BELARMINO, GILIANE; GONZALEZ, MARIA CRISTINA; TORRINHAS, RAQUEL S.; SALA, PRISCILA; ANDRAUS, WELLINGTON; CARNEIRO D'ALBUQUERQUE, LUIZ AUGUSTO; PEREIRA, ROSA MARIA R.; CAPARBO, VALERIA F.; RAVACCI, GRAZIELA R.; DAMIANI, LUCAS; HEYMSFIELD, STEVEN B.; WAITZBERG, DAN L. Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis. WORLD JOURNAL OF HEPATOLOGY, v. 9, n. 7, p. 401-408, MAR 8 2017. Web of Science Citations: 27.
BELARMINO, GILIANE; HORIE, LILIAN MIKA; SALA, PRISCILA CAMPOS; TORRINHAS, RAQUEL S.; HEYMSFIELD, STEVEN B.; WAITZBERG, DAN L. Body adiposity index performance in estimating body fat in a sample of severely obese Brazilian patients. NUTRITION JOURNAL, v. 14, DEC 30 2015. Web of Science Citations: 3.

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