| Texto completo | |
| Autor(es): Mostrar menos - |
Miranda-Furtado, Cristiana L.
[1]
;
Luchiari, Heloise R.
[2]
;
Chielli Pedroso, Daiana C.
[1]
;
Kogure, Gislaine S.
[1]
;
Caetano, Lisandra C.
[1]
;
Santana, Barbara A.
[3]
;
Santana, Viviane P.
[1]
;
Benetti-Pinto, Cristina L.
[4]
;
Reis, Fernando M.
[5]
;
Maciel, Mariella A.
[5]
;
Ferriani, Rui A.
[1]
;
Ramos, Ester S.
[2]
;
Calado, Rodrigo T.
[3]
;
dos Reis, Rosana M.
[1]
Número total de Autores: 14
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Gynecol & Obstet, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto, SP - Brazil
[4] Univ Estadual Campinas, Sch Med Sci, Dept Gynecol & Obstet, Campinas, SP - Brazil
[5] Univ Fed Minas Gerais, Dept Gynecol & Obstet, Belo Horizonte, MG - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Fertility and Sterility; v. 110, n. 3, p. 476+, AUG 2018. |
| Citações Web of Science: | 0 |
| Resumo | |
Objective: To analyze whether telomere length, X-chromosome inactivation (XCI), and androgen receptor (AR) GAG polymorphism arc related to idiopathic premature ovarian insufficiency (POI). Design: Case-control study. Setting: University hospital. Patient(s): A total of 121 women, including 46 nonsyndromic POI and 75 controls. Intervention(s): None. Main Outcome Measure(s): Age, weight, height, body mass index (BMI), systolic and diastolic arterial pressure, E-2, androstenedione, T, and C-reactive protein were assessed. Telomere length was estimated by quantitative real-time polymerase chain reaction, XCI was measured using the Human Androgen Receptor and X-linked retinitis pigmentosa 2 (RP2) methylation assays. AR and FMRI polymorphism was assessed by quantitative fluorescent polymerase chain reaction and sequencing. Result(s): Premature ovarian insufficiency women had a higher mean age, weighed less, and exhibited lower C-reactive protein, E,, and androstenedione levels.The AR polymorphism did not differ between the groups. Four patients had premutation (55-200 CGG repeats), and none displayed a full mutation in the FMRI gene. However, patients with POI showed shorter telomere length and higher frequency of skewed XCI. Extreme skewing (>= 90%) was observed in 15% of women with POI, and shorter telomeres correlated with XCI skewing in both groups. Conclusion(s): Skewed XCI and shortened telomere length were associated with idiopathic POI, despite no alterations in the AR and FMRI genes. Additionally, there is a tendency for women with short telomeres to exhibit skewed XCI. (C) 2018 by American Society for Reproductive Medicine. (AU) | |
| Processo FAPESP: | 12/11566-2 - Polimorfismo cag do receptor de andrógenos e comprimento do telômero em pacientes com falência ovariana prematura |
| Beneficiário: | Rosana Maria dos Reis |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 12/11069-9 - Polimorfismo cag do receptor de andrógenos e comprimento do telômero em pacientes com falência ovariana prematura |
| Beneficiário: | Cristiana Libardi Miranda Furtado |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |