| Texto completo | |
| Autor(es): |
Piccinato, Carla A.
[1, 2]
;
Neme, Rosa M.
[1, 3]
;
Torres, Natalia
[1]
;
Victor, Elivane da Silva
[1]
;
Brudniewski, Heloisa F.
[1, 3]
;
Rosa e Silva, Julio C.
[2]
;
Ferriani, Rui A.
[2]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Hosp Israelita Albert Einstein, Ave Albert Einstein 627, BR-05652 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Obstet & Gynaecol, Sao Paulo - Brazil
[3] Ctr Endometriose Sao Paulo, Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | REPRODUCTIVE SCIENCES; v. 25, n. 9, p. 1371-1375, SEP 2018. |
| Citações Web of Science: | 1 |
| Resumo | |
The cellular function in endometriosis lesions depends on a highly estrogenic milieu. Lately, it is becoming evident that, besides the circulating levels of estrogens, the balance of synthesis versus inactivation (metabolism) of estrogens by intralesion steroid-metabolizing enzymes also determines the local net estrogen availability. In order to extend the knowledge of the role of estrogen-metabolizing enzymes in endometriosis, we investigated the gene and protein expression of a key uridine diphospho-glucuronosyltransferase (UGT) for estrogen glucuronidation, UGT1A1, in eutopic endometrial samples obtained from nonaffected and endometriosis-affected women and also from endometriotic lesions. Although UGT1A1 messenger RNA (mRNA) expression was detected at similar frequencies in endometriotic lesions and in eutopic endometrial samples, the levels of mRNA expression were greater in deep-infiltrating endometriotic lesions and in non-deep-infiltrating lesions when compared with either control endometrium or eutopic endometrium from women with endometriosis. Overall, we observed that protein expression of UGT1A1 was significantly more frequent in samples from endometriotic lesions in comparison with endometria. In addition, expression of UGT1A1 protein was greater in deep-infiltrating than in non-deep-infiltrating endometriotic lesions. We suggest that the finding of increased expression of UGT1A1 in lesions versus endometria might be related to impairment of regulatory mechanisms, in response to a highly estrogenic milieu, and that this enzyme may be a new target for therapy. (AU) | |
| Processo FAPESP: | 10/02412-6 - Estudo do metabolismo local de estrógenos nas lesões peritoneais de mulheres com endometriose |
| Beneficiário: | Carla de Azevedo Piccinato Camargo |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |