The human papillomavirus (HPV)-related cancer biology: An overview

Autor(es)

Araldi, Rodrigo Pinheiro ^[1] ; Sant'Ana, Thalita Araujo ^[2] ; Modolo, Diego Grando ^[2] ; de Melo, Thatiana Correa ^[3] ; Spadacci-Morena, Diva Denelle ^[4] ; Stocco, Rita de Cassia ^[2] ; Cerutti, Janete Maria ^[1] ; de Souza, Edislane Barreiros ^[5]

Afiliação do(s) autor(es)

^[1] Sao Paulo Fed Univ UNIFESP, Genet Basis Thyroid Canc Lab, Sao Paulo, SP - Brazil

^[2] Butantan Inst, Genet Lab, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Med Sch, Haematol & Mol Biol Lab, Sao Paulo, SP - Brazil

^[4] Butantan Inst, Pathophysiol Lab, Sao Paulo, SP - Brazil

^[5] Sao Paulo State Univ UNESP, Fac Sci & Languages, Biotechnol Dept, Genet Lab, BR-19806900 Assis, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: BIOMEDICINE & PHARMACOTHERAPY; v. 106, p. 1537-1556, OCT 2018.
• Citações Web of Science: 6

Resumo

Despite the novel diagnostic methods and therapies implemented in oncology, the number of patients that succumb by the cancer remains high globally. Currently studies point out that 20-25% of all human malignancies are related to micro-organism infections. Among these cancer-related pathogens, the human papillomavirus (HPV) has a prominent position, since the virus is responsible for about 30% of all infectious agentrelated cancers. Thus, an amount of cancers could be avoided by means prophylactic and/or therapeutic measures. However, these measures required a holistic comprehension about HPV-related cancer biology. Based on this, this review aims to summarize the last evidences of HPV on cancer biology (from initiation to metastasis), focus on molecular and biochemical deregulations associated with viral infection, and discuss the viral etiology in different malignancies. (AU)

• Processo FAPESP: 17/14948-7 - Estudo do papel de LIMD2 na transição epitélio-mesênquima no câncer de tiroide
• Beneficiário: Rodrigo Pinheiro Araldi
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/20617-5 - Estudo da ação do papilomavírus bovino (BPV) na transição epitélio-mesênquima
• Beneficiário: Rodrigo Pinheiro Araldi
• Modalidade de apoio: Bolsas no Brasil - Doutorado